Follicular Helper CD4 T Cells (T FH )

PD-1 and Its Ligands in Tolerance and Immunity

Keir, M. E., Butte, M. J., Freeman, G. J., & Sharpe, A. H. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090331 · Cited by 5,378 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 3,960 · see citing works

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062 · see citing works

Effector and memory T-cell differentiation: implications for vaccine development

Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865 · see citing works

IL-17 family cytokines and the expanding diversity of effector T cell lineages

Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842 · see citing works

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works

CD4 T cells: fates, functions, and faults

Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,804 · see citing works

Germinal Centers

MacLennan, I. C. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001001 · Cited by 1,728 · see citing works

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720 · see citing works

The lineage decisions of helper T cells

MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,675 · see citing works

Molecular mechanism and function of CD40/CD40L engagement in the immune system

Elgueta, R., Benson, M. J., de Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,633 · see citing works

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626 · see citing works

Plasticity of CD4+ T Cell Lineage Differentiation

Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · see citing works

The IL-4 receptor: signaling mechanisms and biologic functions

Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545 · see citing works

Bcl6 mediates the development of T follicular helper cells

Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506 · see citing works

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482 · see citing works

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., & Förster, R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1545 · Cited by 1,464 · see citing works

Plasma cell differentiation requires the transcription factor XBP-1

Reimold, A., Iwakoshi, N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E., Friend, D., Grusby, M., Alt, F., & Glimcher, L. (2001) · Nature · doi:10.1038/35085509 · Cited by 1,371 · see citing works

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells

O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,338 · see citing works

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,284 · see citing works

A chemokine-driven positive feedback loop organizes lymphoid follicles

Ansel, K. M., Ngo, V. N., Hyman, P. L., Luther, S. A., Förster, R., Sedgwick, J. D., Browning, J. L., Lipp, M., & Cyster, J. G. (2000) · Nature · doi:10.1038/35018581 · Cited by 1,282 · see citing works

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P., & Moser, B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1553 · Cited by 1,263 · see citing works

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258 · see citing works

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

Yu, D., Rao, S., Tsai, L. M., Lee, S. K., He, Y., Sutcliffe, E. L., Srivastava, M., Linterman, M. A., Zheng, L., Simpson, N., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.07.002 · Cited by 1,216 · see citing works

STAT3 Mutations in the Hyper-IgE Syndrome

Holland, S. M., DeLeo, F. R., Elloumi, H. Z., Hsu, A. P., Uzel, G., Brodsky, N. N., Freeman, A. F., Demidowich, A. P., Davis, J., Turner, M. L. C., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073687 · Cited by 1,214 · see citing works

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205 · see citing works

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

Grivennikov, S. I., & Karin, M. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.005 · Cited by 1,160 · see citing works

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T.-Y., Watford, W. T., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.009 · Cited by 1,152 · see citing works

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

Förster, R., Mattis, A. E., Kremmer, E., Wolf, E., Brem, G., & Lipp, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81798-5 · Cited by 1,129 · see citing works

Molecular Mechanisms of Antibody Somatic Hypermutation

Noia, J. M. D., & Neuberger, M. S. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.061705.090740 · Cited by 1,108 · see citing works

Mechanism of antigen-driven selection in germinal centres

Liu, Y.-J., Joshua, D., Williams, G. T., Smith, C. A., Gordon, J., & Maclennan, I. C. M. (1989) · Nature · doi:10.1038/342929a0 · Cited by 1,080 · see citing works

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

Shaffer, A. L., Shelef, M. A., Iwakoshi, N. N., Lee, A., Qian, S., Zhao, H., Yu, X., Yang, L., Tan, B. K., Rosenwald, A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.010 · Cited by 1,060 · see citing works

Late Developmental Plasticity in the T Helper 17 Lineage

Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053 · see citing works

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara, T., Kawamura, N., Ariga, T., Pasic, S., Stojković, O., et al. (2007) · Nature · doi:10.1038/nature06096 · Cited by 987 · see citing works

Germinal-Center Organization and Cellular Dynamics

Allen, C. D. C., Okada, T., & Cyster, J. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.009 · Cited by 986 · see citing works

A Critical Role for IL-21 in Regulating Immunoglobulin Production

Ozaki, K., Spolski, R., Feng, C. G., Qi, C.-F., Cheng, J., Sher, A., Morse, H. C., Liu, C., Schwartzberg, P. L., & Leonard, W. J. (2002) · Science · doi:10.1126/science.1077002 · Cited by 978 · see citing works

IL-21 and TGF-β are required for differentiation of human TH17 cells

Yang, L., Anderson, D. E., Baecher‐Allan, C., Hastings, W. D., Bettelli, E., Oukka, M., Kuchroo, V. K., & Hafler, D. A. (2008) · Nature · doi:10.1038/nature07021 · Cited by 926 · see citing works

Germinal centres: role in B-cell physiology and malignancy

Klein, U., & Dalla‐Favera, R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2217 · Cited by 899 · see citing works

Regulation of plasma-cell development

Shelef, M. A., & Calame, K. L. (2005) · Nature reviews. Immunology · doi:10.1038/nri1572 · Cited by 881 · see citing works

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Vinuesa, C. G., Cook, M. C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K. M., Yu, D., Domaschenz, H., Whittle, B., Lambe, T., et al. (2005) · Nature · doi:10.1038/nature03555 · Cited by 862 · see citing works

RNA virus error catastrophe: Direct molecular test by using ribavirin

Crotty, S., Cameron, C. E., & Andino, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111085598 · Cited by 853 · see citing works

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851 · see citing works

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846 · see citing works

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

Shelef, M. A., Lin, K., McHeyzer‐Williams, L. J., Liao, J., McHeyzer‐Williams, M. G., & Calame, K. L. (2003) · Immunity · doi:10.1016/s1074-7613(03)00267-x · Cited by 839 · see citing works

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

Gunn, M. D., Ngo, V. N., Ansel, K. M., Ekland, E. H., Cyster, J. G., & Williams, L. T. (1998) · Nature · doi:10.1038/35876 · Cited by 825 · see citing works

Cytokine-secreting follicular T cells shape the antibody repertoire

Reinhardt, R. L., Liang, H.-E., & Locksley, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1715 · Cited by 807 · see citing works

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5

Allen, C. D. C., Ansel, K. M., Low, C., Lesley, R., Tamamura, H., Fujii, N., & Cyster, J. G. (2004) · Nature Immunology · doi:10.1038/ni1100 · Cited by 803 · see citing works

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Linterman, M. A., Beaton, L., Yu, D., Ramiscal, R. R., Srivastava, M., Hogan, J. J., Verma, N. K., Smyth, M. J., Rigby, R. J., & Vinuesa, C. G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091738 · Cited by 803 · see citing works

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

Tay, S., Hughey, J., Lee, T. K., Lipniacki, T., Quake, S. R., & Covert, M. W. (2010) · Nature · doi:10.1038/nature09145 · Cited by 790 · see citing works

Imaging of Germinal Center Selection Events During Affinity Maturation

Allen, C. D. C., Okada, T., Tang, H. L., & Cyster, J. G. (2006) · Science · doi:10.1126/science.1136736 · Cited by 784 · see citing works

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

Zotos, D., Coquet, J. M., Zhang, Y., Light, A., D’Costa, K., Kallies, A., Corcoran, L. M., Godfrey, D. I., Toellner, K., Smyth, M. J., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091777 · Cited by 780 · see citing works

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

Garside, P., Ingulli, E. G., Merica, R. R., Johnson, J. G., Noelle, R. J., & Jenkins, M. K. (1998) · Science · doi:10.1126/science.281.5373.96 · Cited by 774 · see citing works

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

Fife, B. T., Pauken, K. E., Eagar, T. N., Kangas, T. O., Wu, J. Q., Tang, Q., Azuma, M., Krummel, M. F., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1790 · Cited by 759 · see citing works

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

Durant, L. R., Watford, W. T., Ramos, H. L., Laurence, A. D. J., Vahedi, G., Wei, L., Takahashi, H., Sun, H., Kanno, Y., Powrie, F. M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.003 · Cited by 731 · see citing works

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

Grimbacher, B., Hutloff, A., Schlesier, M., Glocker, E. O., Warnatz, K., Dräger, R., Eibel, H., Fischer, B., Schäffer, A. A., Mages, H. W., et al. (2003) · Nature Immunology · doi:10.1038/ni902 · Cited by 731 · see citing works

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K. (2010) · Nature Immunology · doi:10.1038/ni.1912 · Cited by 725 · see citing works

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.68 · Cited by 722 · see citing works

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

Stoll, S., Delon, J., Brotz, T. M., & Germain, R. N. (2002) · Science · doi:10.1126/science.1071065 · Cited by 718 · see citing works

Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

Hsu, H., Yang, P., Wang, J., Wu, Q., Myers, R. C., Chen, J., Yi, J. S., Guentert, T., Tousson, A., Stanus, A. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1552 · Cited by 717 · see citing works

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

Bauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I.-C., Sharpe, A. H., & Kuchroo, V. K. (2009) · Nature Immunology · doi:10.1038/ni.1690 · Cited by 713 · see citing works

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

Rigaud, S., Fondanèche, M., Lambert, N., Pasquier, B., Mateo, V., Soulas-Sprauel, P., Galicier, L., Deist, F. L., Rieux‐Laucat, F., Revy, P., et al. (2006) · Nature · doi:10.1038/nature05257 · Cited by 703 · see citing works

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

Spolski, R. J., & Leonard, W. J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090316 · Cited by 697 · see citing works

Cutting edge: long-term B cell memory in humans after smallpox vaccination

Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L., & Ahmed, R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4969 · Cited by 695 · see citing works

Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation

Haynes, N. M., Allen, C. D. C., Lesley, R., Ansel, K. M., Killeen, N. P., & Cyster, J. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5099 · Cited by 694 · see citing works

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

Good‐Jacobson, K. L., Szumilas, C. G., Chen, L., Sharpe, A. H., Tomayko, M. M., & Shlomchik, M. J. (2010) · Nature Immunology · doi:10.1038/ni.1877 · Cited by 694 · see citing works

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

Simpson, N., Gatenby, P. A., Wilson, A., Malik, S., Fulcher, D. A., Tangye, S. G., Manku, H., Vyse, T. J., Roncador, G., Huttley, G. A., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25032 · Cited by 683 · see citing works

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

Ettinger, R., Sims, G. P., Fairhurst, A., Robbins, R., Silva, Y. S. D., Spolski, R. J., Leonard, W. J., & Lipsky, P. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.7867 · Cited by 675 · see citing works

ICOS is essential for effective T-helper-cell responses

Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S. K., Jordana, M., Wakeham, A. C., Boucher, L.-M., Bouchard, D., Chan, V. S. F., Duncan, G. S., et al. (2001) · Nature · doi:10.1038/35051113 · Cited by 674 · see citing works

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

Ozaki, K., Spolski, R., Ettinger, R., Kim, H.-P., Wang, G., Qi, C.-F., Hwu, P., Shaffer, D. J., Akilesh, S., Roopenian, D. C., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5361 · Cited by 668 · see citing works

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in <i>STAT3</i>

Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., & Cook, M. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080218 · Cited by 652 · see citing works

ICOS is critical for CD40-mediated antibody class switching

McAdam, A. J., Greenwald, R. J., Levin, M. A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G. J., & Sharpe, A. H. (2001) · Nature · doi:10.1038/35051107 · Cited by 644 · see citing works

IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner

Wei, L., Laurence, A. D. J., Elias, K. M., & O’Shea, J. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705100200 · Cited by 641 · see citing works

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models*

Finkelman, F. D., Shea‐Donohue, T., Goldhill, J., Sullivan, C. A., Morris, S. C., Madden, K. B., Gause, W. C., & Urban, J. F. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.505 · Cited by 640 · see citing works

SAP-controlled T–B cell interactions underlie germinal centre formation

Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N. (2008) · Nature · doi:10.1038/nature07345 · Cited by 637 · see citing works

The AP-1 transcription factor Batf controls TH17 differentiation

Schraml, B. U., Hildner, K. M., Ise, W., Lee, W.-L., Smith, W. A.-E., Solomon, B. D., Sahota, G., Sim, J. E., Mukasa, R., Čemerski, S., et al. (2009) · Nature · doi:10.1038/nature08114 · Cited by 632 · see citing works

T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

King, C., Tangye, S. G., & Mackay, C. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090344 · Cited by 632 · see citing works

Subspecialization of Cxcr5+ T Cells

Kim, C. H., Rott, L. S., Clark‐Lewis, I., Campbell, D., Wu, L., & Butcher, E. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.12.1373 · Cited by 621 · see citing works

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

Rutishauser, R. L., Martins, G. A., Kalachikov, S. M., Chandele, A., Parish, I. A., Meffre, E., Jacob, J., Calame, K. L., & Kaech, S. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.014 · Cited by 612 · see citing works

B-Cell Stimulatory Factor-1/Interleukin 4

Paul, W. E., & Ohara, J. (1987) · Annual Review of Immunology · doi:10.1146/annurev.iy.05.040187.002241 · Cited by 608 · see citing works

NFAT, immunity and cancer: a transcription factor comes of age

Müller, M., & Rao, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2818 · Cited by 601 · see citing works

Follicular Helper T Cells: Lineage and Location

Fazilleau, N., Mark, L., McHeyzer‐Williams, L. J., & McHeyzer‐Williams, M. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.003 · Cited by 593 · see citing works

Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches

Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S., & Fagarasan, S. (2009) · Science · doi:10.1126/science.1169152 · Cited by 592 · see citing works

Follicular helper T cells are required for systemic autoimmunity

Linterman, M. A., Rigby, R. J., Wong, R. K., Yu, D., Brink, R. A., Cannons, J. L., Schwartzberg, P. L., Cook, M., Walters, G. D., & Vinuesa, C. G. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081886 · Cited by 588 · see citing works

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Okada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O’Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 586 · see citing works

Generation of Memory B Cells and Plasma Cells in Vitro

Arpin, C., Déchanet, J., van Kooten, C., et al. (1995) · Science · doi:10.1126/science.7537388 · Cited by 580 · see citing works

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

Croft, M. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101243 · Cited by 549 · see citing works

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

Banchereau, J., Paoli, P. D., Vallé, A., et al. (1991) · Science · doi:10.1126/science.1702555 · Cited by 544 · see citing works

Humoral immune responses in CD40 ligand-deficient mice.

Renshaw, B. R., Fanslow, W. C., Armitage, R. J., Campbell, K., Liggitt, D., Wright, B., Davison, B. L., & Maliszewski, C. R. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1889 · Cited by 536 · see citing works

Proinflammatory T helper type 17 cells are effective B-cell helpers

Mitsdoerffer, M., Lee, Y., Jäger, A., Kim, H.-J., Korn, T., Kolls, J. K., Cantor, H., Bettelli, E., & Kuchroo, V. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009234107 · Cited by 534 · see citing works

The effects of IL-6 on CD4 T cell responses

Dienz, O., & Rincón, M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.018 · Cited by 529 · see citing works

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

Crotty, S., Johnston, R. J., & Schoenberger, S. P. (2010) · Nature Immunology · doi:10.1038/ni.1837 · Cited by 525 · see citing works

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

Kallies, A., Xin, A., Belz, G. T., & Nutt, S. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.021 · Cited by 505 · see citing works

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

Yi, J. S., Du, M., & Zajac, A. J. (2009) · Science · doi:10.1126/science.1175194 · Cited by 501 · see citing works

Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells

Bryant, V. L., Ma, C. S., Avery, D. T., Li, Y., Good‐Jacobson, K. L., Corcoran, L. M., Malefyt, R. D. W., & Tangye, S. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8180 · Cited by 498 · see citing works

SLAM Family Receptors and SAP Adaptors in Immunity

Cannons, J. L., Tangye, S. G., & Schwartzberg, P. L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101302 · Cited by 495 · see citing works

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. N., & Ahmed, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407192101 · Cited by 495 · see citing works

In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

Ansel, K. M., McHeyzer‐Williams, L. J., Ngo, V. N., McHeyzer‐Williams, M. G., & Cyster, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.8.1123 · Cited by 494 · see citing works

Effector T cell plasticity: flexibility in the face of changing circumstances

Murphy, K. M., & Stockinger, B. (2010) · Nature Immunology · doi:10.1038/ni.1899 · Cited by 482 · see citing works

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

Shin, H., Blackburn, S. D., Intlekofer, A. M., Kao, C., Angelosanto, J., Reiner, S. L., & Wherry, E. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.019 · Cited by 481 · see citing works

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers

Han, S., Hathcock, K. S., Zheng, B. Q., Kepler, T. B., Hodes, R. J., & Kelsoe, G. H. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.2.556 · Cited by 480 · see citing works

BCoR, a novel corepressor involved in BCL-6 repressionPreprint

Huynh, K. D., Fischle, W., Verdin, E. M., & Bardwell, V. J. (2000) · Genes & Development · doi:10.1101/gad.14.14.1810 · Cited by 475 · see citing works

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

Grewal, I. S., Xu, J., & Flavell, R. A. (1995) · Nature · doi:10.1038/378617a0 · Cited by 472 · see citing works

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

Pot, C., Jin, H., Awasthi, A., Liu, S. M., Lai, C.-Y., Madan, R., Sharpe, A. H., Karp, C. L., Miaw, S., Ho, I., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901233 · Cited by 466 · see citing works

Dysregulation of germinal centres in autoimmune disease

Vinuesa, C. G., Sanz, I., & Cook, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2637 · Cited by 465 · see citing works

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

Fazilleau, N., McHeyzer‐Williams, L. J., Rosen, H., & McHeyzer‐Williams, M. G. (2009) · Nature Immunology · doi:10.1038/ni.1704 · Cited by 452 · see citing works

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

Foy, T. M., Laman, J. D., Ledbetter, J. A., Aruffo, A. A., Claassen, E., & Noelle, R. J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.157 · Cited by 440 · see citing works

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

Dienz, O., Eaton, S. M., Bond, J. P., Neveu, W. A., Moquin, D., Noubade, R., Briso, E. M., Charland, C., Leonard, W. J., Ciliberto, G., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081571 · Cited by 440 · see citing works

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

Liu, Y., Mason, D. Y., Johnson, G. D., Abbot, S. D., Gregory, C. D., Hardie, D. L., Gordon, J., & MacLennan, I. C. M. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210819 · Cited by 435 · see citing works

Primary B Cell Immunodeficiencies: Comparisons and Contrasts

Conley, M. E., Dobbs, K., Farmer, D. M., Kilic, S., Paris, K., Grigoriadou, S., Coustan‐Smith, E., Howard, V. C., & Campana, D. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132649 · Cited by 429 · see citing works

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

Yusuf, I., Kageyama, R., Monticelli, L. A., Johnston, R. J., Ditoro, D. F., Hansen, K., Barnett, B. E., & Crotty, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903505 · Cited by 421 · see citing works

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

Allen, C. D. C., & Cyster, J. G. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.12.001 · Cited by 421 · see citing works

SAP is required for generating long-term humoral immunity

Crotty, S., Kersh, E. N., Cannons, J. L., Schwartzberg, P. L., & Ahmed, R. (2003) · Nature · doi:10.1038/nature01318 · Cited by 419 · see citing works

An epigenetic view of helper T cell differentiation

Ansel, K. M., Lee, D. U., & Rao, A. (2003) · Nature Immunology · doi:10.1038/ni0703-616 · Cited by 419 · see citing works

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

Odegard, J., Marks, B. R., DiPlacido, L. D., Poholek, A. C., Kono, D. H., Dong, C., Flavell, R. A., & Craft, J. E. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080840 · Cited by 418 · see citing works

Regulation and functions of Blimp-1 in T and B lymphocytes.

Martins, G., & Calame, K. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090241 · Cited by 416 · see citing works

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

van Essen, D., Kikutani, H., & Gray, D. (1995) · Nature · doi:10.1038/378620a0 · Cited by 414 · see citing works

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Avery, D. T., Deenick, E. K., Ma, C. S., Suryani, S., Simpson, N., Chew, G., Chan, T. D., Palendira, U., Bustamante, J. C., Boisson‐Dupuis, S., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091706 · Cited by 410 · see citing works

IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

King, I. L., & Mohrs, M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090313 · Cited by 393 · see citing works

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

Bossaller, L., Burger, J. A., Draeger, R., Grimbacher, B., Knoth, R., Plebani, A., Durandy, A., Baumann, U., Schlesier, M., Welcher, A. A., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4927 · Cited by 389 · see citing works

A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma

Saito, M., Gao, J., Basso, K., Kitagawa, Y., Smith, P. M., Bhagat, G., Pernis, A. B., Pasqualucci, L., & Dalla‐Favera, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.011 · Cited by 386 · see citing works

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

Cannons, J. L., Qi, H., Lu, K. T., Dutta, M., Gómez‐Rodríguez, J., Cheng, J., Wakeland, E. K., Germain, R. N., & Schwartzberg, P. L. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.010 · Cited by 384 · see citing works

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

Zaretsky, A. G., Taylor, J. J., King, I. L., Marshall, F. A., Mohrs, M., & Pearce, E. J. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090303 · Cited by 384 · see citing works

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

Kim, J. I., Ho, I., Grusby, M. J., & Glimcher, L. H. (1999) · Immunity · doi:10.1016/s1074-7613(00)80073-4 · Cited by 383 · see citing works

The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo

Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J., Tezuka, K., Yagita∥, H., & Okumura, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2340 · Cited by 375 · see citing works

B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

Warnatz, K., Salzer, U., Rizzi, M., Fischer, B., Gutenberger, S., Böhm, J., Kienzler, A., Pan‐Hammarström, Q., Hammarström, L. L. G., Rakhmanov, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903543106 · Cited by 368 · see citing works

Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma

Dorfman, D. M., Brown, J. A., Shahsafaei, A., & Freeman, G. J. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000209855.28282.ce · Cited by 359 · see citing works

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

Kwon, H., Thierry‐Mieg, D., Thierry‐Mieg, J., Kim, H., Oh, J., Tunyaplin, C., Carotta, S., Donovan, C. E., Goldman, M. L., Tailor, P. B., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.008 · Cited by 357 · see citing works

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

Schmitt, N., Morita, R., Bourdery, L., Bentebibel, S.-E., Zurawski, S., Banchereau, J., & Ueno, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.016 · Cited by 357 · see citing works

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

Flynn, S., Toellner, K.-M., Raykundalia, C., Goodall, M., & Lane, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.297 · Cited by 351 · see citing works

Follicular Dendritic Cells as Accessory Cells

Tew, J. G., Kosco, M. H., Burton, G. F., et al. (1990) · Immunological Reviews · doi:10.1111/j.1600-065x.1990.tb00573.x · Cited by 349 · see citing works

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

Deenick, E. K., Chan, A., Ma, C. S., Gatto, D., Schwartzberg, P. L., Brink, R. A., & Tangye, S. G. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.015 · Cited by 347 · see citing works

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12

Ma, C. S., Suryani, S., Avery, D. T., Chan, A., Nanan, R. K. H., Santner‐Nanan, B., Deenick, E. K., & Tangye, S. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.64 · Cited by 345 · see citing works

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

Phan, R. T., Saito, M., Basso, K., Niu, H., & Dalla-Favera, R. (2005) · Nature Immunology · doi:10.1038/ni1245 · Cited by 343 · see citing works

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

Takahashi, Y., Dutta, P. R., Cerasoli, D. M., & Kelsoe, G. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.885 · Cited by 342 · see citing works

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

Dhordain, P., Albagli, O., Lin, R. J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J., Evans, R. M., & Leprince, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10762 · Cited by 336 · see citing works

Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo

Shakhar, G., Lindquist, R. L., Skokos, D., Dudziak, D., Huang, J. H. Y., Nussenzweig, M. C., & Dustin, M. L. (2005) · Nature Immunology · doi:10.1038/ni1210 · Cited by 333 · see citing works

Fundamental Immunology

Li, J. T. (2009) · JAMA · doi:10.1001/jama.2009.719 · Cited by 332 · see citing works

MTA3 and the Mi-2/NuRD Complex Regulate Cell Fate during B Lymphocyte Differentiation

Fujita, N., Jaye, D. L., Geigerman, C., Akyildiz, A., Mooney, M. R., Boss, J. M., & Wade, P. A. (2004) · Cell · doi:10.1016/j.cell.2004.09.014 · Cited by 328 · see citing works

Essential Role of IL-21 in B Cell Activation, Expansion, and Plasma Cell Generation during CD4+ T Cell-B Cell Collaboration

Kuchen, S., Robbins, R., Sims, G. P., Sheng, C., Phillips, T. M., Lipsky, P. E., & Ettinger, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5886 · Cited by 326 · see citing works

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

Köpf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B., & Bachmann, M. F. (1999) · Immunity · doi:10.1016/s1074-7613(00)80144-2 · Cited by 321 · see citing works

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

Chattopadhyay, P. K., Yu, J., & Roederer, M. (2005) · Nature Medicine · doi:10.1038/nm1293 · Cited by 321 · see citing works

Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression

Rasheed, A. U., Rahn, H.-P., Sallusto, F., Lipp, M., & Müller, G. (2006) · European Journal of Immunology · doi:10.1002/eji.200636136 · Cited by 316 · see citing works

Cutting Edge: IL-21 Is a Switch Factor for the Production of IgG1 and IgG3 by Human B Cells

Pène, J., Gauchat, J., Lécart, S., Drouet, É., Guglielmi, P., Boulay, V., Delwail, A., Foster, D., Lecron, J., & Yssel, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5154 · Cited by 313 · see citing works

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

Liu, Y., Malisan, F., de BOUTEILLER, O., Guret, C., Lebecque, S., Banchereau, J., Mills, F. C., Max, E. E., & Martínez-Valdez, H. (1996) · Immunity · doi:10.1016/s1074-7613(00)80432-x · Cited by 311 · see citing works

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

Ding, B. B., Yu, J., Yu, R. Y.-L., Mendez, L., Shaknovich, R., Zhang, Y., Cattoretti, G., & Ye, B. H. (2007) · Blood · doi:10.1182/blood-2007-04-087734 · Cited by 298 · see citing works

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

Hardtke, S., Ohl, L., & Förster, R. (2005) · Blood · doi:10.1182/blood-2004-11-4494 · Cited by 297 · see citing works

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

Kwakkenbos, M. J., Diehl, S. A., Yasuda, E., Bakker, A. Q., van Geelen, C. M. M., Lukens, M. V., van Bleek, G. M., Widjojoatmodjo, M. N., Bogers, W. M. J. M., Mei, H. E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2071 · Cited by 297 · see citing works

IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-4

Avery, D. T., Bryant, V. L., Ma, C. S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1767 · Cited by 292 · see citing works

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factorPreprint

Niu, H., Ye, B. H., & Dalla‐Favera, R. (1998) · Genes & Development · doi:10.1101/gad.12.13.1953 · Cited by 292 · see citing works

The functional plasticity of T cell subsets

Bluestone, J. A., Mackay, C. R., O’Shea, J. J., & Stockinger, B. (2009) · Nature reviews. Immunology · doi:10.1038/nri2654 · Cited by 285 · see citing works

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency

Warnatz, K. (2005) · Blood · doi:10.1182/blood-2005-07-2955 · Cited by 281 · see citing works

In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development

Poholek, A. C., Hansen, K., Hernandez, S. G., Eto, D. S., Chandele, A., Weinstein, J. S., Dong, X., Odegard, J., Kaech, S. M., Dent, A. L., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904023 · Cited by 279 · see citing works

Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-21

Good‐Jacobson, K. L., Bryant, V. L., & Tangye, S. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5236 · Cited by 279 · see citing works

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

Walker, L. S. K., Gulbranson‐Judge, A., Flynn, S., Brocker, T., Raykundalia, C., Goodall, M. D., Förster, R., Lipp, M., & Lane, P. J. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.8.1115 · Cited by 275 · see citing works

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

Mukasa, R., Balasubramani, A., Lee, Y. K., Whitley, S. K., Weaver, B. T., Shibata, Y., Crawford, G. E., Hatton, R. D., & Weaver, C. T. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.016 · Cited by 273 · see citing works

Association of Extensive Polymorphisms in the SLAM/CD2 Gene Cluster with Murine Lupus

Wandstrat, A. E., Nguyen, C., Limaye, N., Chan, A. Y. K., Subramanian, S., Tian, X.-H., Yim, Y., Pertsemlidis, A., Garner, H. R., Morel, L. M., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.009 · Cited by 258 · see citing works

Fas Is Required for Clonal Selection in Germinal Centers and the Subsequent Establishment of the Memory B Cell Repertoire

Takahashi, Y., Ohta, H., & Takemori, T. (2001) · Immunity · doi:10.1016/s1074-7613(01)00100-5 · Cited by 257 · see citing works

Unique gene expression program of human germinal center T helper cells

Kim, C. H., Lim, H. W., Kim, J., Rott, L. S., Hillsamer, P., & Butcher, E. C. (2004) · Blood · doi:10.1182/blood-2004-03-1206 · Cited by 257 · see citing works

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

Kupfer, A., Mosmann, T. R., & Kupfer, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.775 · Cited by 255 · see citing works

Memory B cells: Effectors of long‐lived immune responses

Tangye, S. G., & Tarlinton, D. M. (2009) · European Journal of Immunology · doi:10.1002/eji.200939531 · Cited by 253 · see citing works

BCL-6 expression during B-cell activation

Allman, D., Jain, A., Dent, A. L., Maile, R., Selvaggi, T. A., Kehry, M. R., & Staudt, L. M. (1996) · Blood · doi:10.1182/blood.v87.12.5257.bloodjournal87125257 · Cited by 251 · see citing works

The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut

Suzuki, K., Maruya, M., Kawamoto, S., Sitnik, K., Kitamura, H., Agace, W. W., & Fagarasan, S. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.003 · Cited by 250 · see citing works

CD28 is required for germinal center formation

Ferguson, S. E., Han, S., Kelsoe, G. H., & Thompson, C. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.12.4576 · Cited by 248 · see citing works

An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

Jourdan, M., Caraux, A., Vos, J. D., Fiol, G., Larroque, M., Cognot, C., Bret, C., Duperray, C., Hose, D., & Klein, B. (2009) · Blood · doi:10.1182/blood-2009-07-235960 · Cited by 247 · see citing works

Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells

Basso, K., Saito, M., Sumazin, P., Margolin, A. A., Wang, K., Lim, W.-K., Kitagawa, Y., Schneider, C., Alvarez, M. J., Califano, A., et al. (2009) · Blood · doi:10.1182/blood-2009-06-227017 · Cited by 246 · see citing works

Development and characterization of IL-21–producing CD4+ T cells

Suto, A., Kashiwakuma, D., Kagami, S., Hirose, K., Watanabe, N., Yokote, K., Saito, Y., Nakayama, T., Grusby, M. J., Iwamoto, I., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072057 · Cited by 246 · see citing works

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

Gigoux, M., Shang, J., Pak, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911573106 · Cited by 241 · see citing works

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

Ci, W., Polo, J. M., Cerchietti, L. C. A., Shaknovich, R., Wang, L., Yang, S. N., Ye, K. Q., Farinha, P., Horsman, D. E., Gascoyne, R. D., et al. (2009) · Blood · doi:10.1182/blood-2008-12-193037 · Cited by 240 · see citing works

Batf coordinates multiple aspects of B and T cell function required for normal antibody responses

Betz, B. C., Jordan-Williams, K. L., Wang, C., Kang, S. G., Liao, J., Logan, M. R., Kim, C. H., & Taparowsky, E. J. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091548 · Cited by 240 · see citing works

Regulation of B Cell Tolerance by the Lupus Susceptibility Gene Ly108

Kumar, K. R., Li, L., Yan, M., Bhaskarabhatla, M., Mobley, A. B., Nguyen, C., Mooney, J. M., Schatzle, J. D., Wakeland, E. K., & Mohan, C. (2006) · Science · doi:10.1126/science.1125893 · Cited by 232 · see citing works

SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

Cannons, J. L., Yu, L. J., Hill, B. J., Mijares, L. A., Dombroski, D. G., Nichols, K. E., Antonellis, A., Koretzky, G. A., Gardner, K. L., & Schwartzberg, P. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.012 · Cited by 232 · see citing works

Immunological memory in humans

Crotty, S., & Ahmed, R. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.008 · Cited by 228 · see citing works

STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation

Diehl, S. A., Schmidlin, H., Nagasawa, M., van Haren, S. D., Kwakkenbos, M. J., Yasuda, E., Beaumont, T., Scheeren, F. A., & Spits, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4805 · Cited by 227 · see citing works

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression

Dhordain, P., Quief, S., Lantoine, D., Kerckaert, J., Albagli, O., Lin, R. J., & Evans, R. M. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.20.4645 · Cited by 227 · see citing works

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

Rolf, J., Bell, S. E., Kövesdi, D., Janas, M. L., Soond, D. R., Webb, L. M. C., Santinelli, S., Saunders, T., Hebeis, B. J., Killeen, N. P., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001730 · Cited by 226 · see citing works

Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM

Murphy, T. L., & MURPHY, K. M. M. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101202 · Cited by 223 · see citing works

Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics

Good‐Jacobson, K. L., & Shlomchik, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001155 · Cited by 221 · see citing works

Vaccine immunology

Siegrist, C. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-3611-1.50006-4 · Cited by 215 · see citing works

Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

Nichols, K. E., Ma, C. S., Cannons, J. L., Schwartzberg, P. L., & Tangye, S. G. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00230.x · Cited by 214 · see citing works

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

Martínez-Valdez, H., Guret, C., de BOUTEILLER, O., Fugier, I., Banchereau, J., & Liu, Y. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.971 · Cited by 214 · see citing works

ICOS deficiency in patients with common variable immunodeficiency

Salzer, U., Maul‐Pavicic, A., Cunningham‐Rundles, C., et al. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.07.002 · Cited by 201 · see citing works

Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene

Vasanwala, F. H., Kusam, S., Toney, L. M., & Dent, A. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1922 · Cited by 199 · see citing works

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

Eddahri, F., Denanglaire, S., Bureau, F., Spolski, R. J., Leonard, W. J., Léo, O., & Andris, F. (2008) · Blood · doi:10.1182/blood-2008-04-154682 · Cited by 197 · see citing works

Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component

Köpf, M., Herren, S., Wiles, M. V., Pepys, M. B., & Kosco‐Vilbois, M. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1895 · Cited by 197 · see citing works

Induction of long-lived germinal centers associated with persisting antigen after viral infection.

Bachmann, M. F., Odermatt, B., Hengartner, H., & Zinkernagel, R. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.5.2259 · Cited by 194 · see citing works

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

Celli, S., Lemaı̂tre, F., & Bousso, P. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.018 · Cited by 194 · see citing works

Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome.

Agematsu, K., Nagumo, H., Shinozaki, K., Hokibara, S., Yasui, K., Terada, K., Kawamura, N., Toba, T., Nonoyama, S., Ochs, H. D., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3409 · Cited by 194 · see citing works

Plasma cell differentiation and survival

Tarlinton, D. M., Radbruch, A., Hiepe, F., & Dörner, T. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.016 · Cited by 187 · see citing works

Th1 and Th2 CD4+ T Cells Provide Help for B Cell Clonal Expansion and Antibody Synthesis in a Similar Manner In Vivo

Smith, K. M., Pottage, L., Thomas, E. R., Leishman, A. J., Doig, T. N., Xu, D., Liew, F. Y., & Garside, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3136 · Cited by 185 · see citing works

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

Glasmacher, E., Hoefig, K. P., Vogel, K. U., Rath, N., Du, L., Wolf, C., Kremmer, E., Wang, X., & Heissmeyer, V. (2010) · Nature Immunology · doi:10.1038/ni.1902 · Cited by 184 · see citing works

Shouts, whispers and the kiss of death: directional secretion in T cells

Huse, M., Quann, E. J., & Davis, M. M. (2008) · Nature Immunology · doi:10.1038/ni.f.215 · Cited by 183 · see citing works

Human genetics of infectious diseases: between proof of principle and paradigm

Alcaïs, A., Abel, L., & Casanova, J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38111 · Cited by 182 · see citing works

Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases

Quintana‐Murci, L., Alcaïs, A., Abel, L., & Casanova, J. (2007) · Nature Immunology · doi:10.1038/ni1535 · Cited by 180 · see citing works

Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism

Dufort, F. J., Bleiman, B. F., Gumina, M. R., Blair, D., Wagner, D. J., Roberts, M. F., Abu‐Amer, Y., & Chiles, T. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.4953 · Cited by 174 · see citing works

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070 · see citing works

T follicular helper cell differentiation, function, and roles in disease

Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847 · see citing works

Germinal Centers

Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878 · see citing works

T follicular helper cell biology: a decade of discovery and diseases

Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591 · see citing works

A Validated Regulatory Network for Th17 Cell Specification

Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160 · see citing works

Dynamics of B cells in germinal centres

De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084 · see citing works

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

Monaco, G., Lee, B., Xu, W., Mustafah, S., Hwang, Y. Y., Carré, C., Burdin, N., Visan, L., Ceccarelli, M., Poidinger, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.041 · Cited by 958 · see citing works

Dendritic-Cell-Based Therapeutic Cancer Vaccines

Palucka, K., & Banchereau, J. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.004 · Cited by 869 · see citing works

The who's who of <scp>T</scp> ‐cell differentiation: Human memory <scp>T</scp> ‐cell subsets

Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817 · see citing works

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

Painter, M. M., Mathew, D., Goel, R. R., Apostolidis, S. A., Pattekar, A., Kuthuru, O., Baxter, A. E., Herati, R. S., Oldridge, D. A., Gouma, S., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.001 · Cited by 499 · see citing works

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507 · see citing works

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

Hirota, K., Turner, J.-E., Villa, M., Duarte, J. H., Demengeot, J., Steinmetz, O. M., & Stockinger, B. (2013) · Nature Immunology · doi:10.1038/ni.2552 · Cited by 509 · see citing works

T cell responses: naïve to memory and everything in between

Pennock, N. D., White, J. T., Cross, E. W., Cheney, E. E., Tamburini, B. A., & Kedl, R. M. (2013) · Advances in Physiology Education · doi:10.1152/advan.00066.2013 · Cited by 461 · see citing works

Molecular programming of B cell memory

McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449 · see citing works

<scp>NF</scp>‐κB: roles and regulation in different <scp>CD</scp>4⁺ T‐cell subsets

Oh, H., & Ghosh, S. (2013) · Immunological Reviews · doi:10.1111/imr.12033 · Cited by 408 · see citing works

T cell-mediated regulation of the microbiota protects against obesity

Petersen, C., Bell, R., Klag, K. A., Lee, S.-H., Soto, R., Ghazaryan, A., Buhrke, K., Ekiz, H. A., Ost, K. S., Boudina, S., et al. (2019) · Science · doi:10.1126/science.aat9351 · Cited by 385 · see citing works

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

Gu-Trantien, C., Migliori, E., Buisseret, L., de Wind, A., Brohée, S., Garaud, S., Noël, G., Dang Chi, V. L., Lodewyckx, J.-N., Naveaux, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91487 · Cited by 368 · see citing works

Regulation of the Germinal Center Response

Stebegg, M., Kumar, S. D., Silva-Cayetano, A., Fonseca, V. R., Linterman, M. A., & Graca, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02469 · Cited by 349 · see citing works

PD-1hi identifies a novel regulatory b-cell population in human hepatoma that promotes disease progression

Xiao, X., Lao, X.-M., Chen, M.-M., Liu, R.-X., Wei, Y., Ouyang, F.-Z., Chen, D.-P., Zhao, X.-Y., Zhao, Q., Li, X.-F., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1408 · Cited by 352 · see citing works

CD4+ T cell memory

Künzli, M., & Masopust, D. (2023) · Nature Immunology · doi:10.1038/s41590-023-01510-4 · Cited by 338 · see citing works

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., & O'Shea, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075058 · Cited by 342 · see citing works

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Kubinak, J. L., Petersen, C., Stephens, W. Z., Soto, R., Bake, E., O’Connell, R. M., & Round, J. L. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.12.009 · Cited by 328 · see citing works

Intestinal IgA production and its role in host-microbe interaction

Gutzeit, C., Magri, G., & Cerutti, A. (2014) · Immunological Reviews · doi:10.1111/imr.12189 · Cited by 332 · see citing works

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

Ray, J. P., Staron, M. M., Shyer, J. A., Ho, P.-C., Marshall, H. D., Gray, S. M., Laidlaw, B. J., Araki, K., Ahmed, R., Kaech, S. M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.017 · Cited by 315 · see citing works

Peripheral Blood Mononuclear Cells

Kleiveland, C. R. (2015) · The Impact of Food Bioactives on Health · doi:10.1007/978-3-319-16104-4_15 · Cited by 295 · see citing works

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

Teng, F., Klinger, C. N., Felix, K. M., Bradley, C. P., Wu, E., Tran, N. L., Umesaki, Y., & Wu, H.-J. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.013 · Cited by 281 · see citing works

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120127 · Cited by 263 · see citing works

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

Végran, F., Berger, H., Boidot, R., Mignot, G., Bruchard, M., Dosset, M., Chalmin, F., Rébé, C., Dérangère, V., Ryffel, B., et al. (2014) · Nature Immunology · doi:10.1038/ni.2925 · Cited by 228 · see citing works

The Th17 family: flexibility follows function

Basu, R., Hatton, R. D., & Weaver, C. T. (2013) · Immunological Reviews · doi:10.1111/imr.12035 · Cited by 229 · see citing works

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

Choi, J., & Crotty, S. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.02.002 · Cited by 190 · see citing works

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Herati, R. S., Reuter, M. A., Dolfi, D. V., Mansfield, K. D., Aung, H., Badwan, O. Z., Kurupati, R. K., Kannan, S., Ertl, H., Schmader, K. E., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302503 · Cited by 177 · see citing works

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer’s patches to promote host-microbiota mutualism

Proietti, M., Cornacchione, V., Rezzonico Jost, T., Romagnani, A., Faliti, C. E., Perruzza, L., Rigoni, R., Radaelli, E., Caprioli, F., Preziuso, S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.010 · Cited by 181 · see citing works

Control of inflammation by integration of environmental cues by regulatory T cells

Chaudhry, A., & Rudensky, A. Y. (2013) · Journal of Clinical Investigation · doi:10.1172/jci57175 · Cited by 183 · see citing works

Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets

Fang, D., & Zhu, J. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170494 · Cited by 175 · see citing works

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

Oja, A. E., Piet, B., Helbig, C., Stark, R., van der Zwan, D., Blaauwgeers, H., Remmerswaal, E. B. M., Amsen, D., Jonkers, R. E., Moerland, P. D., et al. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.94 · Cited by 160 · see citing works

Repositioning TH cell polarization from single cytokines to complex help

Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-01009-w · Cited by 171 · see citing works

Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target

Chen, J., Liu, Q., He, J., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958790 · Cited by 164 · see citing works

Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

Herati, R. S., Muselman, A., Vella, L., Bengsch, B., Parkhouse, K., Del Alcazar, D., Kotzin, J., Doyle, S. A., Tebas, P., Hensley, S. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag2152 · Cited by 167 · see citing works

Induction of robust B cell responses after influenza mRNA vaccination Is accompanied by circulating hemagglutinin-specific ICOS+ PD-1+ CXCR3+ T follicular helper cells

Lindgren, G., Ols, S., Liang, F., Thompson, E. A., Lin, A., Hellgren, F., Bahl, K., John, S., Yuzhakov, O., Hassett, K. J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01539 · Cited by 132 · see citing works

B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation

Barnett, L. G., Simkins, H. M. A., Barnett, B. E., Korn, L. L., Johnson, A. L., Wherry, E. J., Wu, G. F., & Laufer, T. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301284 · Cited by 123 · see citing works

The impact of senescence-associated T cells on immunosenescence and age-related disorders

Fukushima, Y., Minato, N., & Hattori, M. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0082-9 · Cited by 118 · see citing works

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Baeza Garcia, A., Siu, E., Sun, T., Exler, V., Brito, L., Hekele, A., Otten, G., Augustijn, K., Janse, C. J., Ulmer, J. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05041-7 · Cited by 97 · see citing works

T follicular helper cell-dependent clearance of a persistent virus infection requires T cell expression of the histone demethylase UTX

Cook, K. D., Shpargel, K. B., Starmer, J., Whitfield-Larry, F., Conley, B., Allard, D. E., Rager, J. E., Fry, R. C., Davenport, M. L., Magnuson, T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.002 · Cited by 83 · see citing works

Host-microbiota interactions and adaptive immunity

McCoy, K. D., Ronchi, F., & Geuking, M. B. (2017) · Immunological Reviews · doi:10.1111/imr.12575 · Cited by 77 · see citing works

Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6 ⁺ B helper T cells in systemic lupus erythematosus

Facciotti, F., Larghi, P., Bosotti, R., Vasco, C., Gagliani, N., Cordiglieri, C., Mazzara, S., Ranzani, V., Rottoli, E., Curti, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917834117 · Cited by 63 · see citing works

Could lymphocyte profiling be useful to diagnose systemic autoimmune diseases?

Carvajal Alegria, G., Gazeau, P., Hillion, S., Daïen, C. I., & Cornec, D. Y. K. (2017) · Clinical Reviews in Allergy &amp; Immunology · doi:10.1007/s12016-017-8608-5 · Cited by 60 · see citing works

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

Duan, Y.-Q., Xia, M.-H., Ren, L., Zhang, Y.-F., Ao, Q.-L., Xu, S.-P., Kuang, D., Liu, Q., Yan, B., Zhou, Y.-W., et al. (2020) · Current Medical Science · doi:10.1007/s11596-020-2225-x · Cited by 59 · see citing works

Effects of gut microbiota on host adaptive immunity under immune homeostasis and tumor pathology state

Li, Y., Ye, Z., Zhu, J., Fang, S., Meng, L., & Zhou, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844335 · Cited by 45 · see citing works

Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer

Herzog, R. W., Cooper, M., Perrin, G. Q., Biswas, M., Martino, A. T., Morel, L., Terhorst, C., & Hoffman, B. E. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2017.07.012 · Cited by 39 · see citing works

Epigenetic dysfunction in Turner syndrome immune cells

Thrasher, B. J., Hong, L. K., Whitmire, J. K., & Su, M. A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0612-y · Cited by 28 · see citing works

Anti-PD-1 Antibody Therapy Induces Hashimoto’s Disease with an Increase in Peripheral Blood Follicular Helper T Cells

Torimoto, K., Okada, Y., Nakayamada, S., Kubo, S., & Tanaka, Y. (2017) · Thyroid · doi:10.1089/thy.2017.0062 · Cited by 20 · see citing works

Germinal center formation, immunoglobulin production and hindlimb nociceptive sensitization after tibia fracture

Li, W.-W., Yang, Y., Shi, X.-Y., Guo, T.-Z., Guang, Q., Kingery, W. S., Herzenberg, L. A., & Clark, J. D. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.029 · Cited by 18 · see citing works

Identification of inducible HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency

Gallego-Cortés, A., Sánchez-Gaona, N., Mancebo-Pérez, C., Ruiz-Isant, O., Benítez-Martínez, A., Landolfi, S., Castellví, J., Pumarola, F., Ortiz, N., Llano, I., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65288-9 · Cited by 12 · see citing works

Smad1 Expression in Follicular Lymphoma

Go, J. H. (2015) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2015.03.30

New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes

Bunting, K. L., & Melnick, A. M. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.003 · Cited by 75 · see citing works

Roles of BCL6 in normal and transformed germinal center B cells

Basso, K., & Dalla‐Favera, R. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01112.x · Cited by 431 · see citing works

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

Fukuda, T., Yoshida, T., Okada, S., Hatano, M., Miki, T., Ishibashi, K., Okabe, S., Koseki, H., Hirosawa, S., Taniguchi, M., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.3.439 · Cited by 356 · see citing works

Роль экспрессии генов c-MYC, bcl2 и BCL6 в патогенезе диффузной В-крупноклеточной лимфомы

Мисюрина, А. Е., Мисюрин, В. А., Варях, Е. А., et al. (2014) · Клиническая онкогематология. Фундаментальные исследования и клиническая практика