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Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes
Abstract
Clathrin-mediated endocytosis involves cycles of assembly and disassembly of clathrin coat components and their accessory proteins. Dephosphorylation of rat brain extract was shown to promote the assembly of dynamin 1, synaptojanin 1, and amphiphysin into complexes that also included clathrin and AP-2. Phosphorylation of dynamin 1 and synaptojanin 1 inhibited their binding to amphiphysin, whereas phosphorylation of amphiphysin inhibited its binding to AP-2 and clathrin. Thus, phosphorylation regulates the association and dissociation cycle of the clathrin-based endocytic machinery, and calcium-dependent dephosphorylation of endocytic proteins could prepare nerve terminals for a burst of endocytosis.
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Cited by
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
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Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Metadata
- Authors
- Slepnev, V. I., Ochoa, G.-C., Butler, M. H., Grabs, D., & Camilli, P. D.
- Venue
- Science
- Published
- 1998-08-07
- Volume
- 281
- Issue
- 5378
- Pages
- 821-824
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024272753
- Cited by
- 311
- References
- 0
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Slepnev, V. I., Ochoa, G.-C., Butler, M. H., Grabs, D., & Camilli, P. D. (1998). Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes. Science. https://doi.org/10.1126/science.281.5378.821
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
