The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Impaired Spatial Learning after Saturation of Long-Term Potentiation
Abstract
If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.
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“However, although there is considerable evidence linking LTP to behavior memory (45, 441–443), more evidence is needed to solidify this link.”
From Synaptic memory and CaMKII (2023) · cites this paper as [442]
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
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Developments of a water-maze procedure for studying spatial learning in the rat
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Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736
Self-citationImpaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
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Self-citation
Research works printed but not linked: 3
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Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Self-citationApplications of the Morris water maze in the study of learning and memory
D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,083
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Metadata
- Authors
- Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M.
- Affiliations
- University of Oslo (NO)
- Corresponding author
- Moser, Edvard I.
- Venue
- Science
- Published
- 1998-09-25
- Volume
- 281
- Issue
- 5385
- Pages
- 2038-2042
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095510381
- Cited by
- 505
- References
- 31
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 16 · 2015: 18 · 2014: 27 · 2013: 19 · 2012: 25
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, spatial learning, hippocampus, hippocampal lesions, synaptic plasticity, hippocampal formation
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Synapses, Tetany, Long-Term Potentiation, Maze Learning, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats
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