The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Force and Velocity Measured for Single Molecules of RNA Polymerase
Abstract
RNA polymerase (RNAP) moves along DNA while carrying out transcription, acting as a molecular motor. Transcriptional velocities for single molecules of Escherichia coli RNAP were measured as progressively larger forces were applied by a feedback-controlled optical trap. The shapes of RNAP force-velocity curves are distinct from those of the motor enzymes myosin or kinesin, and indicate that biochemical steps limiting transcription rates at low loads do not generate movement. Modeling the data suggests that high loads may halt RNAP by promoting a structural change which moves all or part of the enzyme backwards through a comparatively large distance, corresponding to 5 to 10 base pairs. This contrasts with previous models that assumed force acts directly upon a single-base translocation step.
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Citations
Cites
Force and velocity measured for single kinesin molecules
Svoboda, K., & Block, S. M. (1994) · Cell · doi:10.1016/0092-8674(94)90060-4 · Cited by 909
Self-citationCONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY
Johnson, K. A. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003345 · Cited by 560
Cited by
Single kinesin molecules studied with a molecular force clamp
Visscher, K., Schnitzer, M. J., & Block, S. M. (1999) · Nature · doi:10.1038/22146 · Cited by 1,027
Self-citationShaping the future of manipulation
Dholakia, K., & Čižmár, T. (2011) · Nature Photonics · doi:10.1038/nphoton.2011.80 · Cited by 941
Probing Gene Expression in Live Cells, One Protein Molecule at a Time
Yu, J., Xiao, J., Ren, X., Lao, K., & Xie, X. S. (2006) · Science · doi:10.1126/science.1119623 · Cited by 918
Direct observation of base-pair stepping by RNA polymerase
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R., & Block, S. M. (2005) · Nature · doi:10.1038/nature04268 · Cited by 855
Self-citationForce production by single kinesin motors
Schnitzer, M. J., Visscher, K., & Block, S. M. (2000) · Nature Cell Biology · doi:10.1038/35036345 · Cited by 572
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Metadata
- Authors
- Wang, M. D., Schnitzer, M. J., Yin, H., Landick, R., Gelles, J., & Block, S. M.
- Venue
- Science
- Published
- 1998-10-30
- Volume
- 282
- Issue
- 5390
- Pages
- 902-907
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982433583
- Cited by
- 892
- References
- 2
- FWCI
- 22.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, M. D., Schnitzer, M. J., Yin, H., Landick, R., Gelles, J., & Block, S. M. (1998). Force and Velocity Measured for Single Molecules of RNA Polymerase. Science. https://doi.org/10.1126/science.282.5390.902
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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