The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Binding of Hepatitis C Virus to CD81
Abstract
Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B lymphocyte proliferative disorder. Virus tropism is controversial, and the mechanisms of cell entry remain unknown. The HCV envelope protein E2 binds human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes. Binding of E2 was mapped to the major extracellular loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.
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Citations
Cites
Hepatitis C: the clinical spectrum of disease.
Hoofnagle, J. H. (1997) · Hepatology · doi:10.1002/hep.510260703 · Cited by 765
Cited by
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,854
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Greub, G., Ledergerber, B., Battegay, M., Grob, P., Perrin, L., Furrer, H., Burgisser, P., Erb, P., Boggian, K., Piffaretti, J.-C., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03232-3 · Cited by 894
Ramos-Casals, M., Stone, J. H., Cid, M. C., & Bosch, X. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60242-0 · Cited by 513
Mechanisms for the induction of autoimmunity by infectious agents
Wucherpfennig, K. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14235 · Cited by 435
Metadata
- Authors
- Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A. J., Houghton, M., Rosa, D., Grandi, G., & Abrignani, S.
- Venue
- Science
- Published
- 1998-10-30
- Volume
- 282
- Issue
- 5390
- Pages
- 938-941
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2160174559
- Cited by
- 2,066
- References
- 1
- FWCI
- 47.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Binding of Hepatitis C Virus to CD81. https://app.cochat.ai/papers/10.1126/science.282.5390.938
- The paper
- Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A. J., Houghton, M., Rosa, D., Grandi, G., & Abrignani, S. (1998). Binding of Hepatitis C Virus to CD81. Science. https://doi.org/10.1126/science.282.5390.938
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
