The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals
Open accessAbstract
Many cell surface proteins are marked for endocytosis by a cytoplasmic sequence motif, tyrosine-X-X-(hydrophobic residue), that is recognized by the μ2 subunit of AP2 adaptors. Crystal structures of the internalization signal binding domain of μ2 complexed with the internalization signal peptides of epidermal growth factor receptor and the trans-Golgi network protein TGN38 have been determined at 2.7 angstrom resolution. The signal peptides adopted an extended conformation rather than the expected tight turn. Specificity was conferred by hydrophobic pockets that bind the tyrosine and leucine in the peptide. In the crystal, the protein forms dimers that could increase the strength and specificity of binding to dimeric receptors.
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Cites
Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S., Trowbridge, I. S., & Tainer, J. A. (1990) · Cell · doi:10.1016/0092-8674(90)90509-d · Cited by 518
Cited by
Braulke, T., & Bonifacino, J. S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.10.016 · Cited by 811
Molecular Architecture and Functional Model of the Endocytic AP2 Complex
Collins, B. M., McCoy, A. J., Kent, H. M., Evans, P. R., & Owen, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00735-3 · Cited by 648
Self-citationA Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells
Fölsch, H., Ohno, H., Bonifacino, J. S., & Mellman, I. (1999) · Cell · doi:10.1016/s0092-8674(00)81650-5 · Cited by 467
Adaptors for Clathrin-Mediated Traffic
Kirchhausen, T. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.705 · Cited by 427
Molecular Bases for the Recognition of Tyrosine-based Sorting Signals
Bonifacino, J. S., & Dell'Angelica, E. C. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.923 · Cited by 369
Metadata
- Authors
- Owen, D. J., & Evans, P. R.
- Venue
- Science
- Published
- 1998-11-13
- Volume
- 282
- Issue
- 5392
- Pages
- 1327-1332
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987672004
- Cited by
- 583
- References
- 1
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
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