The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones
Abstract
The inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R) acts as a Ca 2+ release channel on internal Ca 2+ stores. Type 1 IP 3 R (IP 3 R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca 2+ stores and inhibition of IP 3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP 3 R blocker, induced neurite retraction. Acute localized loss of function of IP 3 R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP 3 -induced Ca 2+ release in growth cones appears to have a crucial role in control of nerve growth.
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Citations
Cites
Turning of nerve growth cones induced by neurotransmitters
Zheng, J. Q., Felder, M., Connor, J. A., & Poo, M.-M. (1994) · Nature · doi:10.1038/368140a0 · Cited by 580
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., et al. (1996) · Nature · doi:10.1038/379168a0 · Cited by 485
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Cited by
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Advances in the Treatment of Fragile X Syndrome
Hagerman, R. J., Berry-Kravis, E., Kaufmann, W. E., Ono, M. Y., Tartaglia, N., Lachiewicz, A., Kronk, R., Delahunty, C., Hessl, D., Visootsak, J., et al. (2009) · Pediatrics · doi:10.1542/peds.2008-0317 · Cited by 596
Signal transduction underlying growth cone guidance by diffusible factors
Song, H.-J., & Poo, M.-M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80052-x · Cited by 454
Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators
Patterson, R. L., Boehning, D., & Snyder, S. H. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.161303 · Cited by 441
Higo, T., Hattori, M., Nakamura, T., Natsume, T., Michikawa, T., & Mikoshiba, K. (2005) · Cell · doi:10.1016/j.cell.2004.11.048 · Cited by 373
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Metadata
- Authors
- Takei, K., Shin, R.-M., Inoue, T., Kato, K., & Mikoshiba, K.
- Venue
- Science
- Published
- 1998-11-27
- Volume
- 282
- Issue
- 5394
- Pages
- 1705-1708
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982785144
- Cited by
- 171
- References
- 2
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones. https://app.cochat.ai/papers/10.1126/science.282.5394.1705
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- Takei, K., Shin, R.-M., Inoue, T., Kato, K., & Mikoshiba, K. (1998). Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones. Science. https://doi.org/10.1126/science.282.5394.1705
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