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Zebrafish hox Clusters and Vertebrate Genome Evolution
Abstract
HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.
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Citations
Cited by
The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Self-citationPolyploid incidence and evolution
Otto, S. P., & Whitton, J. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.401 · Cited by 2,363
Jaillon, O., Aury, J.-M., Brunet, F., Petit, J.-L., Stange-Thomann, N., Mauceli, E., Bouneau, L., Fischer, C., Ozouf-Costaz, C., Bernot, A., et al. (2004) · Nature · doi:10.1038/nature03025 · Cited by 1,966
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, J.-M., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A., et al. (2002) · Science · doi:10.1126/science.1072104 · Cited by 1,591
Metadata
- Authors
- Amores, A., Force, A., Yan, Y.-L., Joly, L., Amemiya, C., Fritz, A., Ho, R. K., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., & Postlethwait, J. H.
- Venue
- Science
- Published
- 1998-11-27
- Volume
- 282
- Issue
- 5394
- Pages
- 1711-1714
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2120960764
- Cited by
- 1,736
- References
- 0
- FWCI
- 92.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amores, A., Force, A., Yan, Y.-L., Joly, L., Amemiya, C., Fritz, A., Ho, R. K., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., & Postlethwait, J. H. (1998). Zebrafish hox Clusters and Vertebrate Genome Evolution. Science. https://doi.org/10.1126/science.282.5394.1711
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