The Taxonomy of Developmental Control in Caenorhabditis elegans
Abstract
The Caenorhabditis elegans genome sequence was surveyed for transcription factor and signaling gene families that have been shown to regulate development in a variety of species. About 10 to 25 percent of the genes in most of the gene families already have been genetically analyzed in C. elegans, about half of the genes detect probable orthologs in other species, and about 10 to 25 percent of the genes are, at present, unique to C. elegans. Caenorhabditis elegans is also missing genes that are found in vertebrates and other invertebrates. Thus the genome sequence reveals universals in developmental control that are the legacy of metazoan complexity before the Cambrian explosion, as well as genes that have been more recently invented or lost in particular phylogenetic lineages.
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Comparisons among fruit fly, nematode, and vertebrate genomes show greater genomic complexity in vertebrates as measured by gene content and structure, while many genes and networks are shared across bilaterians.
“Comparisons (4-6) between fruit fly, nematode, and vertebrate genomes reveal greater genomic complexity in the vertebrates (and other deuterostomes (7,8)) as measured by gene content and structure, but at the same time show that many genes and networks are shared across bilaterians.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [5]
The Caenorhabditis elegans genome lacks the Id class of HLH transcription factors.
“Analysis of the Caenorhabditis elegans genome has revealed that the Id class of HLH transcription factors is missing”
From Evolutionary aspects of developmentally regulated helix-loop-helix transcription factors in striated muscle of jellyfish (2003) · cites this paper as Ruvkun and Hobert, 1998
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References 58 · Cited by 305
- Authors
- Ruvkun, G., & Hobert, O.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ruvkun, Gary
- Venue
- Science
- Published
- 1998-12-11
- Volume
- 282
- Issue
- 5396
- Pages
- 2033-2041
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018641010
- Cited by
- 305
- References
- 58
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 2 · 2013: 8 · 2012: 3
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Caenorhabditis elegans, developmental regulation, transcription factors, signaling genes, gene family, orthologs, genome sequence, gene loss, animal evolution, Cambrian explosion
- MeSH terms
- Animals, Genes, Homeobox, Multigene Family, Phylogeny, Transcription Factors, Signal Transduction, Helminth Proteins, Genome, Caenorhabditis elegans, Genes, Helminth, Sequence Analysis, DNA, Gene Expression Regulation, Developmental
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