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Eight Calves Cloned from Somatic Cells of a Single Adult
Abstract
Eight calves were derived from differentiated cells of a single adult cow, five from cumulus cells and three from oviductal cells out of 10 embryos transferred to surrogate cows (80 percent success). All calves were visibly normal, but four died at or soon after birth from environmental causes, and postmortem analysis revealed no abnormality. These results show that bovine cumulus and oviductal epithelial cells of the adult have the genetic content to direct the development of newborn calves.
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Cited by
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Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
Tada, M., Takahama, Y., Abe, K., Nakatsuji, N., & Tada, T. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00459-6 · Cited by 889
Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells
Lanza, R. P., Cibelli, J. B., Blackwell, C., Cristofalo, V. J., Francis, M. K., Baerlocher, G. M., Mak, J., Schertzer, M., Chavez, E. A., Sawyer, N., et al. (2000) · Science · doi:10.1126/science.288.5466.665 · Cited by 466
Loi, P., Ptak, G., Barboni, B., Fulka, J., Cappai, P., & Clinton, M. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-962 · Cited by 458
Genetic Analysis of Inherited Hypertension in the Rat
Rapp, J. P. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.135 · Cited by 422
Metadata
- Authors
- Kato, Y., Tani, T., Sotomaru, Y., Kurokawa, K., Kato, J.-Y., Doguchi, H., Yasue, H., & Tsunoda, Y.
- Venue
- Science
- Published
- 1998-12-11
- Volume
- 282
- Issue
- 5396
- Pages
- 2095-2098
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068196702
- Cited by
- 1,054
- References
- 0
- FWCI
- 39.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Kato, Y., Tani, T., Sotomaru, Y., Kurokawa, K., Kato, J.-Y., Doguchi, H., Yasue, H., & Tsunoda, Y. (1998). Eight Calves Cloned from Somatic Cells of a Single Adult. Science. https://doi.org/10.1126/science.282.5396.2095
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
