The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Global Flexibility in a Sensory Receptor: a Site-Directed Cross-Linking Approach
Abstract
The aspartate receptor of Escherichia coli and Salmonella typhimurium is a cell surface sensory transducer that binds extracellular aspartate and sends a transmembrane signal to the inside of the bacterium. The flexibility and allostery of this receptor was examined by placing sulfhydryl groups as potential cross-linking sites at targeted locations in the protein. Seven different mutant receptors were constructed, each containing a single cysteine residue at a different position in the primary structure. Intramolecular disulfide bond formation within oligomers of these mutant receptors is shown to trap structural fluctuations and to detect ligand-induced changes in structure. The results indicate that the receptor oligomer has a flexible, dynamic structure which undergoes a global change upon aspartate binding.
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Cites
Gene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Cited by
Signal transduction schemes of bacteria
Parkinson, J. S. (1993) · Cell · doi:10.1016/0092-8674(93)90267-t · Cited by 772
Sharff, A. J., Rodseth, L. E., Spurlino, J. C., & Quiocho, F. A. (1992) · Biochemistry · doi:10.1021/bi00159a003 · Cited by 477
Spurlino, J. C., Lu, G.-Y., & Quiocho, F. A. (1992) · Worldwide Protein Data Bank · doi:10.2210/pdb1mbp/pdb · Cited by 458
Spurlino, J. C., Lu, G. Y., & Quiocho, F. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67774-4 · Cited by 455
Milburn, M. V., Privé, G. G., Milligan, D. L., Scott, W. G., Yeh, J., Jancarik, J., Koshland, D. E., & Kim, S.-H. (1991) · Science · doi:10.1126/science.1660187 · Cited by 411
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Metadata
- Authors
- Falke, J. J., & Koshland, D. E.
- Venue
- Science
- Published
- 1987-09-25
- Volume
- 237
- Issue
- 4822
- Pages
- 1596-1600
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976862382
- Cited by
- 244
- References
- 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Falke, J. J., & Koshland, D. E. (1987). Global Flexibility in a Sensory Receptor: a Site-Directed Cross-Linking Approach. Science. https://doi.org/10.1126/science.2820061
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
