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Physiological Role of Silent Receptors of Atrial Natriuretic Factor
Abstract
A ring-deleted analog of atrial natriuretic factor—des[Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANF 4-23 -NH 2 (C-ANF 4-23 )—binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. In this preparation, C-ANF 4-23 is devoid of detectable renal effects and does not antagonize any of the known renal hemodynamic and natriuretic actions of biologically active ANF 1-28 . In contrast, both C-ANF 4-23 and ANF 1-28 increase sodium excretion and decrease blood pressure in intact anesthetized rats. This apparent contradiction is resolved by the finding that the ring-deleted analog markedly increases plasma levels of endogenous immunoreactive ANF in the rat. The results show that the majority of the renal receptors of ANF are biologically silent. This new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANF.
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Citations
Cited by
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
Chinkers, M., Garbers, D. L., Chang, M.-S., Lowe, D. G., Chin, H., Goeddel, D. V., & Schulz, S. (1989) · Nature · doi:10.1038/338078a0 · Cited by 992
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Guanylyl cyclase is a heat-stable enterotoxin receptor
Schulz, S., Green, C. K., Yuen, P. S. T., & Garbers, D. L. (1990) · Cell · doi:10.1016/0092-8674(90)90497-3 · Cited by 601
Matsukawa, N., Grzesik, W. J., Takahashi, N., Pandey, K. N., Pang, S., Yamauchi, M., & Smithies, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7403 · Cited by 455
Role of Calcium in Angiotensin II-Mediated Aldosterone Secretion*
BARRETT, P. Q., BOLLAG, W. B., ISALES, C. M., MCCARTHY, R. T., & RASMUSSEN, H. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-4-496 · Cited by 183
Metadata
- Authors
- Maack, T., Suzuki, M., Almeida, F. A., Nussenzveig, D., Scarborough, R. M., McEnroe, G. A., & Lewicki, J. A.
- Venue
- Science
- Published
- 1987-10-30
- Volume
- 238
- Issue
- 4827
- Pages
- 675-678
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054649519
- Cited by
- 932
- References
- 0
- FWCI
- 70.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maack, T., Suzuki, M., Almeida, F. A., Nussenzveig, D., Scarborough, R. M., McEnroe, G. A., & Lewicki, J. A. (1987). Physiological Role of Silent Receptors of Atrial Natriuretic Factor. Science. https://doi.org/10.1126/science.2823385
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
