The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
Open accessAbstract
Natriuretic peptides (NPs), mainly produced in heart [atrial (ANP) and B-type (BNP)], brain (CNP), and kidney (urodilatin), decrease blood pressure and increase salt excretion. These functions are mediated by natriuretic peptide receptors A and B (NPRA and NPRB) having cytoplasmic guanylyl cyclase domains that are stimulated when the receptors bind ligand. A more abundantly expressed receptor (NPRC or C-type) has a short cytoplasmic domain without guanylyl cyclase activity. NPRC is thought to act as a clearance receptor, although it may have additional functions. To test how NPRC affects the cardiovascular and renal systems, we inactivated its gene ( Npr3 ) in mice by homologous recombination. The half life of [ 125 I]ANP in the circulation of homozygotes lacking NPRC is two-thirds longer than in the wild type, although plasma levels of ANP and BNP in heterozygotes and homozygotes are close to the wild type. Heterozygotes and homozygotes have a progressively reduced ability to concentrate urine, exhibit mild diuresis, and tend to be blood volume depleted. Blood pressure in the homozygotes is 8 mmHg (1 mmHg = 133 Pa) below normal. These results are consistent with the sole cardiovascular/renal function of NPRC being to clear natriuretic peptides, thereby modulating local effects of the natriuretic peptide system. Unexpectedly, Npr3 −/− homozygotes have skeletal deformities associated with a considerable increase in bone turnover. The phenotype is consistent with the bone function of NPRC being to clear locally synthesized CNP and modulate its effects. We conclude that NPRC modulates the availability of the natriuretic peptides at their target organs, thereby allowing the activity of the natriuretic peptide system to be tailored to specific local needs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
Chinkers, M., Garbers, D. L., Chang, M.-S., Lowe, D. G., Chin, H., Goeddel, D. V., & Schulz, S. (1989) · Nature · doi:10.1038/338078a0 · Cited by 992
Physiological Role of Silent Receptors of Atrial Natriuretic Factor
Maack, T., Suzuki, M., Almeida, F. A., Nussenzveig, D., Scarborough, R. M., McEnroe, G. A., & Lewicki, J. A. (1987) · Science · doi:10.1126/science.2823385 · Cited by 932
Suga, S., Nakao, K., Hosoda, K., Mukoyama, M., Ogawa, Y., Shirakami, G., Arai, H., Saito, Y., Kambayashi, Y., & Inouye, K. (1992) · Endocrinology · doi:10.1210/en.130.1.229 · Cited by 739
TAKAHASHI, N., YAMANA, H., YOSHIKI, S., ROODMAN, G. D., MUNDY, G. R., JONES, S. J., BOYDE, A., & SUDA, T. (1988) · Endocrinology · doi:10.1210/endo-122-4-1373 · Cited by 730
Self-citationA Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice
Krege, J. H., Hodgin, J. B., Hagaman, J. R., & Smithies, O. (1995) · Hypertension · doi:10.1161/01.hyp.25.5.1111 · Cited by 587
Self-citationHypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
Oliver, P. M., Fox, J. E., Kim, R., Rockman, H. A., Kim, H.-S., Reddick, R. L., Pandey, K. N., Milgram, S. L., Smithies, O., & Maeda, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14730 · Cited by 576
Self-citationSchulz, S., Singh, S., Bellet, R. A., Singh, G., Tubb, D. J., Chin, H., & Garbers, D. L. (1989) · Cell · doi:10.1016/0092-8674(89)90513-8 · Cited by 547
Krebsbach, P. H., Kuznetsov, S. A., Satomura, K., Emmons, R. V. B., Rowe, D. W., & Robey, P. G. (1997) · Transplantation · doi:10.1097/00007890-199704270-00003 · Cited by 481
Koller, B. H., Hagemann, L. J., Doetschman, T., Hagaman, J. R., Huang, S., Williams, P. J., First, N. L., Maeda, N., & Smithies, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8927 · Cited by 223
Self-citationA simple and sensitive method for the quantitative estimation of collagen
Junqueira, L. C. U., Bignolas, G., & Brentani, R. R. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90795-4 · Cited by 207
Cited by
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
The International Consortium for Blood Pressure Genome-Wide Association Studies (2011) · Nature · doi:10.1038/nature10405 · Cited by 2,033
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Self-citationMusclin is an activity-stimulated myokine that enhances physical endurance
Subbotina, E., Sierra, A., Zhu, Z., Gao, Z., Koganti, S. R. K., Reyes, S., Stepniak, E., Walsh, S. A., Acevedo, M. R., Perez-Terzic, C. M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514250112 · Cited by 198
Natriuretic peptides in cardiometabolic regulation and disease
Zois, N. E., Bartels, E. D., Hunter, I., Kousholt, B. S., Olsen, L. H., & Goetze, J. P. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.64 · Cited by 182
Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
Hemming, M. L., Elias, J. E., Gygi, S. P., & Selkoe, D. J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060257 · Cited by 153
Metadata
- Authors
- Matsukawa, N., Grzesik, W. J., Takahashi, N., Pandey, K. N., Pang, S., Yamauchi, M., & Smithies, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-22
- Volume
- 96
- Issue
- 13
- Pages
- 7403-7408
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059535615
- Cited by
- 455
- References
- 18
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. https://app.cochat.ai/papers/10.1073/pnas.96.13.7403
- The paper
- Matsukawa, N., Grzesik, W. J., Takahashi, N., Pandey, K. N., Pang, S., Yamauchi, M., & Smithies, O. (1999). The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.13.7403
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
