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Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers
Abstract
Molecular recognition based on length was found to occur between oppositely charged pairs of flexible and randomly coiled block copolymers in an aqueous milieu. Matched pairs with the same block lengths of polyanions and polycations exclusively formed even in mixtures with different block lengths. These assemblies of the charged segments with matched chain lengths then formed larger core-shell–type supramolecular assemblies with an extremely narrow size distribution due to the strict phase separation between core- and shell-forming segments.
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Cited by
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
Self-citationBlock copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309
Self-citationAmphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Progress of drug-loaded polymeric micelles into clinical studies
Cabral, H., & Kataoka, K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.042 · Cited by 837
Self-citationBlock copolymer micelles for drug delivery: Design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.013 · Cited by 783
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Metadata
- Authors
- Harada, A., & Kataoka, K.
- Venue
- Science
- Published
- 1999-01
- Volume
- 283
- Issue
- 5398
- Pages
- 65-67
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045573038
- Cited by
- 598
- References
- 0
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harada, A., & Kataoka, K. (1999). Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers. Science. https://doi.org/10.1126/science.283.5398.65
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.