The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Abstract
Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood. Blockade of N -methyl- d -aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival. These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors.
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“For instance, exposure to N-methyl-D-aspartate (NMDA) antagonist, ethanol, or general anesthetics, causes a significant increase in neuronal degeneration at P6–P7456.”
From Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice (2015) · cites this paper as [5]
In the citing paper
“Early post-natal, but not adolescent, deletion of Grin1 in mouse forebrain interneurons reduced their expression of parvalbumin and glutamate decarboxylase 1 (GAD1, also known as GAD67), and caused cortical disinhibition and asynchrony 30,31 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [30]
In the citing paper
“The behavioural deficits induced by interneuronal Grin1 deletion are exacerbated by social isolation stress 30 , which models aspects of known environmental risks for schizophrenia, including childhood maltreatment and psychosocial adverse events 1 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [30]
Citations
Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,151
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY
Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
Ketamine—its pharmacology and therapeutic uses
white, P. F., Way, W. L., & Trevor, A. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00007 · Cited by 1,474
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,223
Modulation of Neuronal Migration by NMDA Receptors
Komuro, H., & RAKIC, P. T. (1993) · Science · doi:10.1126/science.8096653 · Cited by 1,041
GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'
Ben‐Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 807
Ketamine: an update on the first twenty-five years of clinical experience
Reich, D. L., & Silvay, G. (1989) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03011442 · Cited by 707
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
Jevtović‐Todorović, V., Todorovć, S. M., Mennerick, S. J., Powell, S., Dikranian, K. T., Benshoff, N. D., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 675
Self-citationN‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production
Hoffman, P. L., Rabe, C. S., Moses, F. E., & Tabakoff, B. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07280.x · Cited by 566
Grasl‐Kraupp, B. (1995) · Hepatology · doi:10.1016/0270-9139(95)90071-3 · Cited by 517
A cautionary note on the use of the TUNEL stain to determine apoptosis
Charriaut‐Marlangue, C., & Ben‐Ari, Y. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00014 · Cited by 509
Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., & Mizuno, N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903470112 · Cited by 506
Ikonomidou, C., Mosinger, J., Salles, K., Labruyere, J., & Olney, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02809.1989 · Cited by 332
Self-citationSynaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.
Guerrini, L., Blasi, F., & Denis‐Donini, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9077 · Cited by 287
Expression of mRNAs Encoding Subunits of the NMDA Receptor in Developing Rat Brain
Zhong, J., Carrozza, D. P., Williams, K. L., Pritchett, D. B., & Molinoff, P. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020531.x · Cited by 251
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus
Gould, E., Cameron, H. A., & McEwen, B. S. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400408 · Cited by 244
Yan, G.-M., Ni, B., Weller, M., Wood, K. A., & Paul, S. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91364-1 · Cited by 171
An improved cupric-silver method for impregnation of axonal and terminal degeneration
de Olmos, J. S., & Ingram, W. R. (1971) · Brain Research · doi:10.1016/0006-8993(71)90130-2 · Cited by 170
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.
Vezzani, A., Serafini, R., Stasi, M. A., Caccia, S., Conti, I., Tridico, R. V., & SAMANIN, R. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23251-7 · Cited by 165
Alterations in Gait Following Ethanol Exposure During the Brain Growth Spurt in Rats
Meyer, L. S., Kotch, L. E., & Riley, E. P. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb00440.x · Cited by 96
Prenatal Alcohol Exposure and Infant Behavior:
Coles, C. D., Smith, I. E., & Falek, A. (1987) · Advances in Alcohol & Substance Abuse · doi:10.1300/j251v06n04_07 · Cited by 59
Effects of halothane anesthesia on the biodisposition of ketamine in rats.
White, P. F., Marietta, M. P., PUDWILL, C. R., Way, W. L., & Trevor, A. J. (1976) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30448-9 · Cited by 56
Lee, H., & Choi, B. H. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90185-s · Cited by 54
Ethanol neurobehavioural teratogenesis and the role of L -glutamate in the fetal hippocampus
Reynolds, J. D. H., & Brien, J. F. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-173 · Cited by 51
Balázs, R., Hack, N., & Jørgensen, O. S. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90068-d · Cited by 48
Anti-phencyclidine monoclonal Fab fragments markedly alter phencyclidine pharmacokinetics in rats.
Valentine, J. L., Arnold, L. W., & Owens, S. M. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38842-7 · Cited by 43
Kristensen, J. D., HARTVIG, P., Karlsten, R., Gordh, T., & Halldin, M. M. (1995) · British Journal of Anaesthesia · doi:10.1093/bja/74.2.193 · Cited by 30
Kappelle, A. C., Bravenboer, B., van Buren, T., Traber, J., Erkelens, D. W., & Gispen, W. H. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12878.x · Cited by 28
Nimodipine and the recovery of memory
Izquierdo, I. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90229-2 · Cited by 27
Research works printed but not linked: 5
- Cruz-Orive L. L., Weibel E. R., Am. J. Physiol. 258, L148 (1990);
- Ishimaru M. J., Ikonomidou C., Dikranian K., Olney J. W., Soc. Neurosci. Abstr. 23, 895 (1997);
- Vezzani A., et al., J. Pharmacol. Exp. Ther. 249, 278 (1989);
- Valentine J. L., Arnold L. W., Owens S. M., J. Pharmacol. Exp. Ther. 269, 1079 (1994);
- White P. F., Marietta M. P., Pudwill C. R., Way W. L., Trevor A. J., J. Pharmacol. Exp. Ther. 196, 545 (1976);
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Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983
Self-citationExtrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
Glutamate as a neurotransmitter in the brain: review of physiology and pathology
Meldrum, B. S. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.4.1007s · Cited by 1,667
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644
Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C. A., Genz, K., Price, M. T., Stefovska, V. G., Hörster, F., Tenkova, T., et al. (2000) · Science · doi:10.1126/science.287.5455.1056 · Cited by 1,382
Self-citation
Metadata
- Authors
- Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W.
- Affiliations
- Washington University in St. Louis (US)
- C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vöckler, V. Stefovska, Department of Pediatric Neurology, Charité-Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany. K. Dikranian, T. I. Tenkova, J. W. Olney, Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110, USA. L. Turski, Eisai London Research Laboratories, Bernard Katz Building, University College London, Gower Street, London WC1E 6BT, UK.
- Corresponding author
- Ikonomidou, Chrysanthy
- Venue
- Science
- Published
- 1999-01
- Volume
- 283
- Issue
- 5398
- Pages
- 70-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036650593
- Cited by
- 2,055
- References
- 33
- Citations by year
- 2026: 17 · 2025: 36 · 2024: 41 · 2023: 43 · 2022: 49 · 2021: 73 · 2020: 63 · 2019: 148 · 2018: 85 · 2017: 86 · 2016: 112 · 2015: 98 · 2014: 94 · 2013: 92 · 2012: 92
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh038894-20)
- National Institute on Aging (AG11355, P01AG011355)
- National Institute of Mental Health (MH-38894)
- National Institute on Drug Abuse (R01DA005072, DA05072)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- NMDA receptor blockade, apoptosis, neuronal survival, glutamate excitotoxicity, brain development, fetal brain development, neonatal brain development, neurodevelopmental disorders, prenatal drug exposure, pediatric anesthesia, excitatory neurotransmitter
- MeSH terms
- Animals, Brain, Calcium Channel Blockers, Dose-Response Relationship, Drug, Fetus, Haloperidol, Immunohistochemistry, Microscopy, Electron, Nerve Degeneration, Neurons, Quinoxalines, Scopolamine, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Apoptosis, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Muscarinic Antagonists, In Situ Nick-End Labeling, Rats
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