The DOI matches its Crossref record.
A Molecular Mechanism for Electrical Tuning of Cochlear Hair Cells
Abstract
Cochlear frequency selectivity in lower vertebrates arises in part from electrical tuning intrinsic to the sensory hair cells. The resonant frequency is determined largely by the gating kinetics of calcium-activated potassium (BK) channels encoded by the slo gene. Alternative splicing of slo from chick cochlea generated kinetically distinct BK channels. Combination with accessory β subunits slowed the gating kinetics of α splice variants but preserved relative differences between them. In situ hybridization showed that the β subunit is preferentially expressed by low-frequency (apical) hair cells in the avian cochlea. Interaction of β with α splice variants could provide the kinetic range needed for electrical tuning of cochlear hair cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
High-conductance potassium channels of the SLO family
Salkoff, L., Butler, A., Ferreira, G., Santi, C., & Wei, A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1992 · Cited by 536
MECHANISMS OF HAIR CELL TUNING
Fettiplace, R., & Fuchs, P. A. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.809 · Cited by 417
Self-citationLarge-conductance, calcium-activated potassium channels: Structural and functional implications
Ghatta, S., Nimmagadda, D., Xu, X., & O'Rourke, S. T. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.007 · Cited by 330
Ca2+-Activated K+Channels: From Protein Complexes to Function
Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274
Molecular Determinants of BK Channel Functional Diversity and Functioning
Latorre, R., Castillo, K., Carrasquel-Ursulaez, W., Sepulveda, R. V., Gonzalez-Nilo, F., Gonzalez, C., & Alvarez, O. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2016 · Cited by 271
Metadata
- Authors
- Ramanathan, K., Michael, T. H., Jiang, G.-J., Hiel, H., & Fuchs, P. A.
- Venue
- Science
- Published
- 1999-01-08
- Volume
- 283
- Issue
- 5399
- Pages
- 215-217
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079297169
- Cited by
- 180
- References
- 0
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Molecular Mechanism for Electrical Tuning of Cochlear Hair Cells. https://app.cochat.ai/papers/10.1126/science.283.5399.215
- The paper
- Ramanathan, K., Michael, T. H., Jiang, G.-J., Hiel, H., & Fuchs, P. A. (1999). A Molecular Mechanism for Electrical Tuning of Cochlear Hair Cells. Science. https://doi.org/10.1126/science.283.5399.215
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
