The DOI matches its Crossref record.
Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4
Abstract
The vertebrate heart consists of two types of chambers, the atria and the ventricles, which differ in their contractile and electrophysiological properties. Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois -related homeobox gene, Irx4 , was identified that has a ventricle-restricted expression pattern at all stages of heart development. Irx4 protein was shown to regulate the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain–1 ( VMHC1 ) and suppressing the expression of the atrial myosin heavy chain–1 ( AMHC1 ) in the ventricles. Thus, Irx4 may play a critical role in establishing chamber-specific gene expression in the developing heart.
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Citations
Cited by
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Pasumarthi, K. B. S., & Field, L. J. (2002) · Circulation Research · doi:10.1161/01.res.0000020201.44772.67 · Cited by 466
The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation
Chen, C.-M. A., & Cepko, C. L. (2002) · Development · doi:10.1242/dev.00114 · Cited by 293
Self-citationCostantini, D. L., Arruda, E. P., Agarwal, P., Kim, K.-H., Zhu, Y., Zhu, W., Lebel, M., Cheng, C. W., Park, C. Y., Pierce, S. A., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.004 · Cited by 229
Self-citationThe Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development
Cheng, C. W., Chow, R. L., Lebel, M., Sakuma, R., Cheung, H. O.-L., Thanabalasingham, V., Zhang, X., Bruneau, B. G., Birch, D. G., Hui, C.-C., et al. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.029 · Cited by 90
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Metadata
- Authors
- Bao, Z.-Z., Bruneau, B. G., Seidman, J. G., Seidman, C. E., & Cepko, C. L.
- Venue
- Science
- Published
- 1999-02-19
- Volume
- 283
- Issue
- 5405
- Pages
- 1161-1164
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086282126
- Cited by
- 245
- References
- 0
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bao, Z.-Z., Bruneau, B. G., Seidman, J. G., Seidman, C. E., & Cepko, C. L. (1999). Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4. Science. https://doi.org/10.1126/science.283.5405.1161
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