The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Prion Domain Initiation of Amyloid Formation in Vitro from Native Ure2p
Abstract
The [URE3] non-Mendelian genetic element of Saccharomyces cerevisiae is an infectious protein (prion) form of Ure2p, a regulator of nitrogen catabolism. Here, synthetic Ure2p 1−65 were shown to polymerize to form filaments 40 to 45 angstroms in diameter with more than 60 percent β sheet. Ure2p 1−65 specifically induced full-length native Ure2p to copolymerize under conditions where native Ure2p alone did not polymerize. Like Ure2p in extracts of [URE3] strains, these 180- to 220-angstrom-diameter filaments were protease resistant. The Ure2p 1−65 -Ure2p cofilaments could seed polymerization of native Ure2p to form thicker, less regular filaments. All filaments stained with Congo Red to produce the green birefringence typical of amyloid. This self-propagating amyloid formation can explain the properties of [URE3].
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Cites
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Cited by
Prions Affect the Appearance of Other Prions
Derkatch, I. L., Bradley, M. E., Hong, J. Y., & Liebman, S. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00427-5 · Cited by 559
Prions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555
Molecular structure of amyloid fibrils: insights from solid-state NMR
Tycko, R. (2006) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583506004173 · Cited by 527
Amyloid Polymorphism: Structural Basis and Neurobiological Relevance
Tycko, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.017 · Cited by 440
Seeding Specificity in Amyloid Growth Induced by Heterologous Fibrils
O'Nuallain, B., Williams, A. D., Westermark, P., & Wetzel, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311300200 · Cited by 423
Metadata
- Authors
- Taylor, K. L., Cheng, N., Williams, R. W., Steven, A. C., & Wickner, R. B.
- Venue
- Science
- Published
- 1999-02-26
- Volume
- 283
- Issue
- 5406
- Pages
- 1339-1343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969006061
- Cited by
- 277
- References
- 25
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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