The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Exon Shuffling by L1 Retrotransposition
Abstract
Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse transcriptase activity. Engineered L1s retrotranspose at high frequency in cultured human cells. Here it is shown that L1s insert into transcribed genes and retrotranspose sequences derived from their 3′ flanks to new genomic locations. Thus, retrotransposition-competent L1s provide a vehicle to mobilize non-L1 sequences, such as exons or promoters, into existing genes and may represent a general mechanism for the evolution of new genes.
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Citations
Cites
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139
Self-citation
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationPan-cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064
Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
Self-citationDNA transposons and the evolution of eukaryotic genomes.
Feschotte, C., & Pritham, E. J. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090448 · Cited by 1,218
Interspersed repeats and other mementos of transposable elements in mammalian genomes
Smit, A. F. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00031-3 · Cited by 949
Metadata
- Authors
- Moran, J. V., DeBerardinis, R. J., & Kazazian, H. H.
- Venue
- Science
- Published
- 1999-03-05
- Volume
- 283
- Issue
- 5407
- Pages
- 1530-1534
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966285167
- Cited by
- 625
- References
- 1
- FWCI
- 57.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moran, J. V., DeBerardinis, R. J., & Kazazian, H. H. (1999). Exon Shuffling by L1 Retrotransposition. Science. https://doi.org/10.1126/science.283.5407.1530
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
