Mobile Elements: Drivers of Genome Evolution
Abstract
Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome and have shaped both genes and the entire genome. Although the host can often control their numbers, massive expansions of retrotransposons have been tolerated during evolution. Now mobile elements are becoming useful tools for learning more about genome evolution and gene function.
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Transposable elements contain functional subunits that can be exapted and modified by the host genome, and they can mediate duplication of existing CNEs to distant genomic locations.
“Transposable elements contain a variety of functional subunits that can be exapted and modified by the host genome 89,91 , and they can mediate duplication of existing CNEs to distant genomic locations through transduction or chimaerism 92 .”
From Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences (2007) · cites this paper as [92]
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- Authors
- Kazazian, H. H.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Kazazian, Haig H.
- Venue
- Science
- Published
- 2004-03-12
- Volume
- 303
- Issue
- 5664
- Pages
- 1626-1632
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050557699
- Cited by
- 1,922
- References
- 3
- Citations by year
- 2026: 44 · 2025: 60 · 2024: 60 · 2023: 42 · 2022: 64 · 2021: 127 · 2020: 75 · 2019: 69 · 2018: 82 · 2017: 89 · 2016: 74 · 2015: 87 · 2014: 93 · 2013: 114 · 2012: 102
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- transposable elements, genome evolution, retrotransposons, genome expansion, gene function, plants, mammals
- MeSH terms
- Animals, DNA Transposable Elements, Humans, Recombination, Genetic, Genome, Human, Genome, Retroelements, Evolution, Molecular, DNA Methylation, Terminal Repeat Sequences, Long Interspersed Nucleotide Elements, Alu Elements, RNA, Small Interfering
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