The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Single-Molecule Biomechanics with Optical Methods
Abstract
Single-molecule observation and manipulation have come of age. With the advent of optical tweezers and other methods for probing and imaging single molecules, investigators have circumvented the model-dependent extrapolation from ensemble assays that has been the hallmark of classical biochemistry and biophysics. In recent years, there have been important advances in the understanding of how motor proteins work. The range of these technologies has also started to expand into areas such as DNA transcription and protein folding. Here, recent experiments with rotary motors, linear motors, RNA polymerase, and titin are described.
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Citations
Cites
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Force and velocity measured for single kinesin molecules
Svoboda, K., & Block, S. M. (1994) · Cell · doi:10.1016/0092-8674(94)90060-4 · Cited by 909
Direct observation of single kinesin molecules moving along microtubules
Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y., & Yanagida, T. (1996) · Nature · doi:10.1038/380451a0 · Cited by 711
Coupling of kinesin steps to ATP hydrolysis
Hua, W., Young, E. C., Fleming, M. L., & Gelles, J. (1997) · Nature · doi:10.1038/41118 · Cited by 358
Fluctuation analysis of motor protein movement and single enzyme kinetics.
Svoboda, K., Mitra, P. P., & Block, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11782 · Cited by 294
Young, E. C., Mahtani, H. K., & Gelles, J. (1998) · Biochemistry · doi:10.1021/bi972172n · Cited by 59
Cited by
Mechanochemistry: The Mechanical Activation of Covalent Bonds
Beyer, M. K., & Clausen-Schaumann, H. (2005) · Chemical Reviews · doi:10.1021/cr030697h · Cited by 1,303
Stochastic sensors inspired by biology
Bayley, H., & Cremer, P. S. (2001) · Nature · doi:10.1038/35093038 · Cited by 1,118
Recent Advances in Optical Tweezers
Moffitt, J. R., Chemla, Y. R., Smith, S. B., & Bustamante, C. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.043007.090225 · Cited by 1,084
Synthetische molekulare Motoren und mechanische Maschinen
Kay, E. R., Leigh, D. A., & Zerbetto, F. (2007) · Angewandte Chemie · doi:10.1002/ange.200504313 · Cited by 624
Laser-Induced Heating in Optical Traps
Peterman, E. J. G., Gittes, F., & Schmidt, C. F. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74946-7 · Cited by 608
Metadata
- Authors
- Mehta, A. D., Rief, M., Spudich, J. A., Smith, D. A., & Simmons, R. M.
- Venue
- Science
- Published
- 1999-03-12
- Volume
- 283
- Issue
- 5408
- Pages
- 1689-1695
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009439307
- Cited by
- 666
- References
- 6
- FWCI
- 27.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mehta, A. D., Rief, M., Spudich, J. A., Smith, D. A., & Simmons, R. M. (1999). Single-Molecule Biomechanics with Optical Methods. Science. https://doi.org/10.1126/science.283.5408.1689
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