The DOI matches its Crossref record.
Abnormal Spindle Protein, Asp, and the Integrity of Mitotic Centrosomal Microtubule Organizing Centers
Abstract
The product of the abnormal spindle ( asp ) gene was found to be an asymmetrically localized component of the centrosome during mitosis, required to focus the poles of the mitotic spindle in vivo. Removing Asp protein function from Drosophila melanogaster embryo extracts, either by mutation or immunodepletion, resulted in loss of their ability to restore microtubule-organizing center activity to salt-stripped centrosome preparations. This was corrected by addition of purified Asp protein. Thus, Asp appears to hold together the microtubule-nucleating γ-tubulin ring complexes that organize the mitotic centrosome.
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Cited by
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738
Stuck in Division or Passing through
Rieder, C. L., & Maiato, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.002 · Cited by 657
Woods, C. G., Bond, J., & Enard, W. (2005) · The American Journal of Human Genetics · doi:10.1086/429930 · Cited by 431
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
Fish, J. L., Kosodo, Y., Enard, W., Pääbo, S., & Huttner, W. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604066103 · Cited by 421
Re-evaluating centrosome function
Doxsey, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35089575 · Cited by 395
Metadata
- Authors
- do Carmo Avides, M., & Glover, D. M.
- Venue
- Science
- Published
- 1999-03-12
- Volume
- 283
- Issue
- 5408
- Pages
- 1733-1735
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150553603
- Cited by
- 169
- References
- 0
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- do Carmo Avides, M., & Glover, D. M. (1999). Abnormal Spindle Protein, Asp, and the Integrity of Mitotic Centrosomal Microtubule Organizing Centers. Science. https://doi.org/10.1126/science.283.5408.1733
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
