Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Abstract
The dramatic evolutionary expansion of the cerebral cortex of Homo sapiens underlies our unique higher cortical functions, and therefore bears on the ultimate issue of what makes us human. Recent insights into developmental events during early proliferative stages of cortical development indicate how neural stem and progenitor cells might interact to produce cortical expansion during development, and could shed light on evolutionary changes in cortical structure.
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The human neocortex has undergone massive evolutionary expansion, particularly in superficial layers, likely due to differences in rates of progenitor pool expansion during neurogenesis compared to other species.
“For example, the human neocortex has undergone massive evolutionary expansion, particularly in superficial layers, likely due to differences in rates of progenitor pool expansion during neurogenesis compared to other species6.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [6]
MIA model timing is set to roughly mimic infection between 8 to 12 weeks during the first trimester in humans, when neural progenitor cells are proliferating to expand cortical surface area and promote cortical layering.
“This is timed to roughly mimic infection between 8 to 12 weeks during the 1st trimester in humans, when neural progenitor cells are proliferating to expand cortical surface area and promote cortical layering [37, 39].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [39]
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- Authors
- Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kriegstein, Arnold
- Venue
- Nature Reviews Neuroscience
- Published
- 2006-10-11
- Volume
- 7
- Issue
- 11
- Pages
- 883-890
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1970756199
- Cited by
- 738
- References
- 94
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 37 · 2023: 42 · 2022: 24 · 2021: 38 · 2020: 34 · 2019: 44 · 2018: 41 · 2017: 38 · 2016: 40 · 2015: 48 · 2014: 40 · 2013: 45 · 2012: 42
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- neural stem cells, neural progenitor cells, cortical expansion, cerebral cortex evolution, gyrencephaly, cortical development, primate brain evolution, human brain evolution
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Cerebral Cortex, Biological Evolution, Humans, Neuroglia, Neurons, Stem Cells, Gene Expression Regulation, Developmental, Cell Lineage
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