Cited by 738Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion

Kriegstein, Arnold, Noctor, Stephen, Martínez-Cerdeño, Verónica·2006·Nature Reviews Neuroscience

Abstract

The dramatic evolutionary expansion of the cerebral cortex of Homo sapiens underlies our unique higher cortical functions, and therefore bears on the ultimate issue of what makes us human. Recent insights into developmental events during early proliferative stages of cortical development indicate how neural stem and progenitor cells might interact to produce cortical expansion during development, and could shed light on evolutionary changes in cortical structure.

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Crossref · 10.1038/nrn2008

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94 of 94 references verified0 citation errors · 0 not checkable

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  • The human neocortex has undergone massive evolutionary expansion, particularly in superficial layers, likely due to differences in rates of progenitor pool expansion during neurogenesis compared to other species.

    “For example, the human neocortex has undergone massive evolutionary expansion, particularly in superficial layers, likely due to differences in rates of progenitor pool expansion during neurogenesis compared to other species6.”

    From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [6]

  • MIA model timing is set to roughly mimic infection between 8 to 12 weeks during the first trimester in humans, when neural progenitor cells are proliferating to expand cortical surface area and promote cortical layering.

    “This is timed to roughly mimic infection between 8 to 12 weeks during the 1st trimester in humans, when neural progenitor cells are proliferating to expand cortical surface area and promote cortical layering [37, 39].”

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Authors
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V.
Affiliations
University of California, San Francisco (US)
Corresponding author
Kriegstein, Arnold
Venue
Nature Reviews Neuroscience
Published
2006-10-11
Volume
7
Issue
11
Pages
883-890
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W1970756199
Cited by
738
References
94
Citations by year
2026: 14 · 2025: 25 · 2024: 37 · 2023: 42 · 2022: 24 · 2021: 38 · 2020: 34 · 2019: 44 · 2018: 41 · 2017: 38 · 2016: 40 · 2015: 48 · 2014: 40 · 2013: 45 · 2012: 42
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
neural stem cells, neural progenitor cells, cortical expansion, cerebral cortex evolution, gyrencephaly, cortical development, primate brain evolution, human brain evolution
MeSH terms
Animals, Cell Differentiation, Cell Division, Cerebral Cortex, Biological Evolution, Humans, Neuroglia, Neurons, Stem Cells, Gene Expression Regulation, Developmental, Cell Lineage

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