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HLA and HIV-1: Heterozygote Advantage and B*35-Cw*04 Disadvantage
Abstract
A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci (A,B, and C) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus–type 1 (HIV-1), whereas individuals who were homozygous for one or more loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of AIDS-defining conditions in Caucasians. The extended survival of 28 to 40 percent of HIV-1–infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
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Metadata
- Authors
- Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., & O'Brien, S. J.
- Venue
- Science
- Published
- 1999-03-12
- Volume
- 283
- Issue
- 5408
- Pages
- 1748-1752
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995453338
- Cited by
- 1,224
- References
- 1
- FWCI
- 24.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., & O'Brien, S. J. (1999). HLA and HIV-1: Heterozygote Advantage and B*35-Cw*04 Disadvantage. Science. https://doi.org/10.1126/science.283.5408.1748
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
