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Chemical Transformations in Individual Ultrasmall Biomimetic Containers
Abstract
Individual phospholipid vesicles, 1 to 5 micrometers in diameter, containing a single reagent or a complete reaction system, were immobilized with an infrared laser optical trap or by adhesion to modified borosilicate glass surfaces. Chemical transformations were initiated either by electroporation or by electrofusion, in each case through application of a short (10-microsecond), intense (20 to 50 kilovolts per centimeter) electric pulse delivered across ultramicroelectrodes. Product formation was monitored by far-field laser fluorescence microscopy. The ultrasmall characteristic of this reaction volume led to rapid diffusional mixing that permits the study of fast chemical kinetics. This technique is also well suited for the study of reaction dynamics of biological molecules within lipid-enclosed nanoenvironments that mimic cell membranes.
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Cited by
Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device
Thorsen, T., Roberts, R. W., Arnold, F. H., & Quake, S. R. (2001) · Physical Review Letters · doi:10.1103/physrevlett.86.4163 · Cited by 2,051
A vesicle bioreactor as a step toward an artificial cell assembly
Noireaux, V., & Libchaber, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408236101 · Cited by 1,152
Giant Vesicles: Preparations and Applications
Walde, P., Cosentino, K., Engel, H., & Stano, P. (2010) · ChemBioChem · doi:10.1002/cbic.201000010 · Cited by 770
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments
Wei, Z., Li, Y., Cooks, R. G., & Yan, X. (2020) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-121319-110654 · Cited by 631
Metadata
- Authors
- Chiu, D. T., Wilson, C. F., Ryttsén, F., Strömberg, A., Farre, C., Karlsson, A., Nordholm, S., Gaggar, A., Modi, B. P., Moscho, A., Garza-López, R. A., Orwar, O., & Zare, R. N.
- Venue
- Science
- Published
- 1999-03-19
- Volume
- 283
- Issue
- 5409
- Pages
- 1892-1895
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2116343004
- Cited by
- 228
- References
- 0
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chiu, D. T., Wilson, C. F., Ryttsén, F., Strömberg, A., Farre, C., Karlsson, A., Nordholm, S., Gaggar, A., Modi, B. P., Moscho, A., Garza-López, R. A., Orwar, O., & Zare, R. N. (1999). Chemical Transformations in Individual Ultrasmall Biomimetic Containers. Science. https://doi.org/10.1126/science.283.5409.1892
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
