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Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer
Abstract
Tat, the transactivating protein from HIV, forms a metal-linked dimer with metal ions bridging cysteine-rich regions from each monomer. This novel arrangement is distinct from the "zinc finger" domain observed in other eukaryotic regulatory proteins. Ultraviolet absorption spectra show that Tat binds two Zn 2+ or two Cd 2+ ions per monomer, and electrophoresis of the Tat-metal complexes demonstrates that the protein forms metal-linked dimers. Partial proteolysis and circular dichroism spectra suggest that metal binding has its primary effects in the cysteine-rich region and relatively little effect on the folding of other regions. These results suggest new directions for biological studies and new approaches to drug design.
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Cited by
Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins
Kim, D., Kim, C.-H., Moon, J.-I., Chung, Y.-G., Chang, M.-Y., Han, B.-S., Ko, S., Yang, E., Cha, K. Y., Lanza, R., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.005 · Cited by 1,814
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells
Bestor, T., Laudano, A., Mattaliano, R., & Ingram, V. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
GUPTA, B., LEVCHENKO, T., & TORCHILIN, V (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.007 · Cited by 632
Metadata
- Authors
- Frankel, A. D., Bredt, D. S., & Pabo, C. O.
- Venue
- Science
- Published
- 1988-04
- Volume
- 240
- Issue
- 4848
- Pages
- 70-73
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006244184
- Cited by
- 457
- References
- 0
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frankel, A. D., Bredt, D. S., & Pabo, C. O. (1988). Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer. Science. https://doi.org/10.1126/science.2832944
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