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Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association
Abstract
Brownian dynamics computer simulations of the diffusional association of electron transport proteins cytochrome c (cyt c) and cytochrome c peroxidase (cyt c per) were performed. A highly detailed and realistic model of the protein structures and their electrostatic interactions was used that was based on an atomic-level spatial description. Several structural features played a role in enhancing and optimizing the electron transfer efficiency of this reaction. Favorable electrostatic interactions facilitated long-lived nonspecific encounters between the proteins that allowed the severe orientational criteria for reaction to be overcome by rotational diffusion during encounters. Thus a "reduction-in-dimensionality" effect operated. The proteins achieved plausible electron transfer orientations in a multitude of electrostatically stable encounter complexes, rather than in a single dominant complex.
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Citations
Cited by
Protein Radicals in Enzyme Catalysis
Stubbe, J., & van der Donk, W. A. (1998) · Chemical Reviews · doi:10.1021/cr9400875 · Cited by 1,377
Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90015-5 · Cited by 522
Visualization of transient encounter complexes in protein–protein association
Tang, C., Iwahara, J., & Clore, G. M. (2006) · Nature · doi:10.1038/nature05201 · Cited by 406
The Nature of Aqueous Tunneling Pathways Between Electron-Transfer Proteins
Lin, J., Balabin, I. A., & Beratan, D. N. (2005) · Science · doi:10.1126/science.1118316 · Cited by 254
Metadata
- Authors
- Northrup, S. H., Boles, J. O., & Reynolds, J. C. L.
- Venue
- Science
- Published
- 1988-07
- Volume
- 241
- Issue
- 4861
- Pages
- 67-70
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055724834
- Cited by
- 290
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association. https://app.cochat.ai/papers/10.1126/science.2838904
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- Northrup, S. H., Boles, J. O., & Reynolds, J. C. L. (1988). Brownian Dynamics of Cytochrome c and Cytochrome c Peroxidase Association. Science. https://doi.org/10.1126/science.2838904
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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