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Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer
Abstract
Although steroid hormone receptors are known to activate gene expression by binding to specific hormone-dependent enhancers, the mechanisms by which steroids inhibit the transcription of specific genes are unknown. It is shown here by gene transfer studies that the same glucocorticoid receptor that activates gene expression can negatively regulate expression of the human glycoprotein hormone α-subunit gene. Glucocorticoid inhibition was conferred by a 52-nucleotide region that also contains elements crucial both for adenosine 3′,5′-monophosphate (cAMP) responsiveness and for placental-specific expression of this gene and was observed only under conditions in which these elements were functioning as enhancers. Purified glucocorticoid receptor was found to bind to DNA that overlap the cAMP responsive elements sites in this region. It is hypothesized that steroid receptors negatively regulate gene expression by interfering with the activity or binding of other important transcription factors.
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Cited by
The Human Transcription Factors
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Gene regulation by steroid hormones
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“Alternatively, glucocorticoid-mediated repression of both basal and stressinduced CRF and/or AVP expression might result from interference with DNA binding of other transcription factors (Akerblom et al., 1988, Pearce and Yamamoto 1993).”
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Metadata
- Authors
- Akerblom, I. E., Slater, E. P., Beato, M., Baxter, J. D., & Mellon, P. L.
- Venue
- Science
- Published
- 1988-07-15
- Volume
- 241
- Issue
- 4863
- Pages
- 350-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2097228095
- Cited by
- 481
- References
- 0
- FWCI
- 41.87
- Type
- journal article
- Language
- en
- Open access
- closed
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