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Efficient Persistence of Extrachromosomal KSHV DNA Mediated by Latency-Associated Nuclear Antigen
Abstract
Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma–associated herpesvirus (KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA colocalized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA colocalized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. These results support a model in which LANA tethers KSHV DNA to chromosomes during mitosis to enable the efficient segregation of KSHV episomes to progeny cells.
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Cited by
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Moore, P. S., & Chang, Y. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2961 · Cited by 745
Cesarman, E., Damania, B., Krown, S. E., Martin, J., Bower, M., & Whitby, D. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0060-9 · Cited by 697
The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA
Barbera, A. J., Chodaparambil, J. V., Kelley-Clarke, B., Joukov, V., Walter, J. C., Luger, K., & Kaye, K. M. (2006) · Science · doi:10.1126/science.1120541 · Cited by 503
Self-citationKaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays
Jenner, R. G., Albà, M. M., Boshoff, C., & Kellam, P. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.891-902.2001 · Cited by 379
Cotter, M. A., & Robertson, E. S. (1999) · Virology · doi:10.1006/viro.1999.9999 · Cited by 349
Metadata
- Authors
- Ballestas, M. E., Chatis, P. A., & Kaye, K. M.
- Venue
- Science
- Published
- 1999-04-23
- Volume
- 284
- Issue
- 5414
- Pages
- 641-644
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066410692
- Cited by
- 694
- References
- 0
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ballestas, M. E., Chatis, P. A., & Kaye, K. M. (1999). Efficient Persistence of Extrachromosomal KSHV DNA Mediated by Latency-Associated Nuclear Antigen. Science. https://doi.org/10.1126/science.284.5414.641
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
