The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA
Abstract
Kaposi's sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency.
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p12 Tethers the Murine Leukemia Virus Pre-integration Complex to Mitotic Chromosomes
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Chromatin Tethering of Incoming Foamy Virus by the Structural Gag Protein
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Metadata
- Authors
- Barbera, A. J., Chodaparambil, J. V., Kelley-Clarke, B., Joukov, V., Walter, J. C., Luger, K., & Kaye, K. M.
- Venue
- Science
- Published
- 2006-02-10
- Volume
- 311
- Issue
- 5762
- Pages
- 856-861
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995782808
- Cited by
- 503
- References
- 35
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barbera, A. J., Chodaparambil, J. V., Kelley-Clarke, B., Joukov, V., Walter, J. C., Luger, K., & Kaye, K. M. (2006). The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA. Science. https://doi.org/10.1126/science.1120541
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