The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis
Abstract
Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis that allows the suppression of reduction or dehydration reactions at specific biosynthetic steps, giving rise to a wide range of often medically useful products. The lovastatin biosynthesis cluster contains two type I polyketide synthase genes. Synthesis of the main nonaketide-derived skeleton was found to require the previously known iterative lovastatin nonaketide synthase (LNKS), plus at least one additional protein (LovC) that interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L. The noniterative lovastatin diketide synthase (LDKS) enzyme specifies formation of 2-methylbutyrate and interacts closely with an additional transesterase (LovD) responsible for assembling lovastatin from this polyketide and monacolin J.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Cited by
Polyketide biosynthesis: a millennium review
Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,641
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
Bok, J. W., & Keller, N. P. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.527-535.2004 · Cited by 902
Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P. R., Morelli, A., Parks, D. J., & Willson, T. M. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025529g · Cited by 743
Rollini, M. M. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-0932-9 · Cited by 410
Biosynthesis of polyketide synthase extender units
Chan, Y. A., Podevels, A. M., Kevany, B. M., & Thomas, M. G. (2009) · Nat. Prod. Rep. · doi:10.1039/b801658p · Cited by 337
Metadata
- Authors
- Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., & Richard Hutchinson, C.
- Venue
- Science
- Published
- 1999-05-21
- Volume
- 284
- Issue
- 5418
- Pages
- 1368-1372
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031290750
- Cited by
- 654
- References
- 1
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., & Richard Hutchinson, C. (1999). Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis. Science. https://doi.org/10.1126/science.284.5418.1368
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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