The DOI matches its Crossref record.
Broadly Protective Vaccine for Staphylococcus aureus Based on an in Vivo-Expressed Antigen
Abstract
Vaccines based on preferential expression of bacterial antigens during human infection have not been described. Staphylococcus aureus synthesized poly- N -succinyl β-1-6 glucosamine (PNSG) as a surface polysaccharide during human and animal infection, but few strains expressed PNSG in vitro. All S. aureus strains examined carried genes for PNSG synthesis. Immunization protected mice against kidney infections and death from strains that produced little PNSG in vitro. Nonimmune infected animals made antibody to PNSG, but serial in vitro cultures of kidney isolates yielded mostly cells that did not produce PNSG. PNSG is a candidate for use in a vaccine to protect against S. aureus infection.
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Cited by
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiss, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213870 · Cited by 932
Self-citationKey Role of Teichoic Acid Net Charge in Staphylococcus aureus Colonization of Artificial Surfaces
Gross, M., Cramton, S. E., Götz, F., & Peschel, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.3423-3426.2001 · Cited by 554
Impact of the agr Quorum‐Sensing System on Adherence to Polystyrene in Staphylococcus aureus
Vuong, C., Saenz, H. L., Götz, F., & Otto, M. (2000) · The Journal of Infectious Diseases · doi:10.1086/317606 · Cited by 499
Mazmanian, S. K., Liu, G., Jensen, E. R., Lenoy, E., & Schneewind, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080520697 · Cited by 453
Iron-Source Preference of Staphylococcus aureus Infections
Skaar, E. P., Humayun, M., Bae, T., DeBord, K. L., & Schneewind, O. (2004) · Science · doi:10.1126/science.1099930 · Cited by 440
Metadata
- Authors
- McKenney, D., Pouliot, K. L., Wang, Y., Murthy, V., Ulrich, M., Döring, G., Lee, J. C., Goldmann, D. A., & Pier, G. B.
- Venue
- Science
- Published
- 1999-05-28
- Volume
- 284
- Issue
- 5419
- Pages
- 1523-1527
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015509108
- Cited by
- 371
- References
- 0
- FWCI
- 16.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- McKenney, D., Pouliot, K. L., Wang, Y., Murthy, V., Ulrich, M., Döring, G., Lee, J. C., Goldmann, D. A., & Pier, G. B. (1999). Broadly Protective Vaccine for Staphylococcus aureus Based on an in Vivo-Expressed Antigen. Science. https://doi.org/10.1126/science.284.5419.1523
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
