The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Impact of the agr Quorum‐Sensing System on Adherence to Polystyrene in Staphylococcus aureus
Abstract
Biofilm formation by Staphylococcus aureus is a serious problem in nosocomial infections. There are great differences in the capacity of S. aureus to express biofilms, but the reasons are unknown. In all, 105 S. aureus strains were tested for a correlation between the agr quorum-sensing system phenotype and the ability of S. aureus to adhere to polystyrene. Some 78% of agr-negative, but only 6% of agr-positive, strains formed a biofilm, demonstrating a profound impact of agr on biofilm formation. This result was confirmed with defined agr mutants and by inhibition of agr with quorum-sensing blockers. The observed effect was not due to differential expression of the autolysin Atl or of the exopolysaccharide polysaccharide intercellular adhesin but seemed to be caused, at least in part, by the surfactant properties of delta-toxin. The detected biofilm-enhancing effect of S. aureus quorum-sensing blockers call into question the proposed therapeutic use of such substances.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Christensen, G. D., Simpson, W. A., Younger, J. J., Baddour, L. M., Barrett, F. F., Melton, D. M., & Beachey, E. H. (1985) · Journal of Clinical Microbiology · doi:10.1128/jcm.22.6.996-1006.1985 · Cited by 2,255
Balows, A. (1992) · Springer eBooks · Cited by 1,397
Fuqua, C., Winans, S. C., & Greenberg, E. P. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.727 · Cited by 1,209
Cramton, S. E., Gerke, C., Schnell, N. F., Nichols, W. W., & Götz, F. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5427-5433.1999 · Cited by 1,124
Peschel, A., Otto, M., Jack, R. W., Kalbacher, H., Jung, G., & Götz, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8405 · Cited by 994
Self-citationMolecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidis
Heilmann, C., Schweitzer, O., Gerke, C., Vanittanakom, N., Mack, D., & Götz, F. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02548.x · Cited by 922
Self-citationBacterial Interference Caused by Autoinducing Peptide Variants
Ji, G., Beavis, R., & Novick, R. P. (1997) · Science · doi:10.1126/science.276.5321.2027 · Cited by 817
Heilmann, C., Hussain, M., Peters, G., & Götz, F. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4101774.x · Cited by 700
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Cited by
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
McCarthy, H., Rudkin, J. K., Black, N. S., Gallagher, L., O'Neill, E., & O'Gara, J. P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00001 · Cited by 426
Williams, M. R., Costa, S. K., Zaramela, L. S., Khalil, S., Todd, D. A., Winter, H. L., Sanford, J. A., O’Neill, A. M., Liggins, M. C., Nakatsuji, T., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8329 · Cited by 292
Metadata
- Authors
- Vuong, C., Saenz, H. L., Götz, F., & Otto, M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12
- Volume
- 182
- Issue
- 6
- Pages
- 1688-1693
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2122792108
- Cited by
- 499
- References
- 26
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vuong, C., Saenz, H. L., Götz, F., & Otto, M. (2000). Impact of the agr Quorum‐Sensing System on Adherence to Polystyrene in Staphylococcus aureus. The Journal of Infectious Diseases. https://doi.org/10.1086/317606
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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