The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Structure of the Escherichia coli Fumarate Reductase Respiratory Complex
Abstract
The integral membrane protein fumarate reductase catalyzes the final step of anaerobic respiration when fumarate is the terminal electron acceptor. The homologous enzyme succinate dehydrogenase also plays a prominent role in cellular energetics as a member of the Krebs cycle and as complex II of the aerobic respiratory chain. Fumarate reductase consists of four subunits that contain a covalently linked flavin adenine dinucleotide, three different iron-sulfur clusters, and at least two quinones. The crystal structure of intact fumarate reductase has been solved at 3.3 angstrom resolution and demonstrates that the cofactors are arranged in a nearly linear manner from the membrane-bound quinone to the active site flavin. Although fumarate reductase is not associated with any proton-pumping function, the two quinones are positioned on opposite sides of the membrane in an arrangement similar to that of the Q-cycle organization observed for cytochrome bc 1 .
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Protein Structure Comparison by Alignment of Distance Matrices
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Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc 1 Complex
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A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.
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Cited by
Architecture of succinate dehydrogenase and reactive oxygen species generation
Yankovskaya, V., Horsefield, R., Törnroth, S., Luna-Chavez, C., Miyoshi, H., Léger, C., Byrne, B., Cecchini, G., & Iwata, S. (2003) · Science · doi:10.1126/science.1079605 · Cited by 927
Self-citationCrystal Structure of Mitochondrial Respiratory Membrane Protein Complex II
Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M., & Rao, Z. (2005) · Cell · doi:10.1016/j.cell.2005.05.025 · Cited by 881
Direct Electrochemistry of Redox Enzymes as a Tool for Mechanistic Studies
Léger, C., & Bertrand, P. (2008) · Chemical Reviews · doi:10.1021/cr0680742 · Cited by 783
Function and Structure of Complex II of the Respiratory Chain
Cecchini, G. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161700 · Cited by 556
Self-citationDetergents for the stabilization and crystallization of membrane proteins
Privé, G. G. (2007) · Methods · doi:10.1016/j.ymeth.2007.01.007 · Cited by 532
Metadata
- Authors
- Iverson, T. M., Luna-Chavez, C., Cecchini, G., & Rees, D. C.
- Venue
- Science
- Published
- 1999-06-18
- Volume
- 284
- Issue
- 5422
- Pages
- 1961-1966
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093007887
- Cited by
- 416
- References
- 5
- FWCI
- 30.02
- Type
- journal article
- Language
- en
- Open access
- closed
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