The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme
Abstract
Mutants in the gene CDC34 of the yeast Saccharomyces cerevisiae are defective in the transition from G 1 to the S phase of the cell cycle. This gene was cloned and shown to encode a 295-residue protein that has substantial sequence similarity to the product of the yeast RAD6 gene. The RAD6 gene is required for a variety of cellular functions including DNA repair and was recently shown to encode a ubiquitin-conjugating enzyme. When produced in Escherichia coli , the CDC34 gene product catalyzed the covalent attachment of ubiquitin to histones H2A and H2B in vitro, demonstrating that the CDC34 protein is another distinct member of the family of ubiquitin-conjugating enzymes. The cell cycle function of CDC34 is thus likely to be mediated by the ubiquitin-conjugating activity of its product.
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Cites
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686
Rapid similarity searches of nucleic acid and protein data banks.
Wilbur, W. J., & Lipman, D. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.3.726 · Cited by 1,546
Cited by
Cyclin is degraded by the ubiquitin pathway
Glotzer, M., Murray, A. W., & Kirschner, M. W. (1991) · Nature · doi:10.1038/349132a0 · Cited by 2,357
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
Scheffner, M., Huibregtse, J. M., Vierstra, R. D., & Howley, P. M. (1993) · Cell · doi:10.1016/0092-8674(93)90384-3 · Cited by 2,054
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., & Varshavsky, A. (1989) · Science · doi:10.1126/science.2538923 · Cited by 1,535
Self-citationHow Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
Huibregtse, J. M., Scheffner, M., & Howley, P. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04990.x · Cited by 879
Metadata
- Authors
- Goebl, M. G., Yochem, J., Jentsch, S., McGrath, J. P., Varshavsky, A., & Byers, B.
- Venue
- Science
- Published
- 1988-09-09
- Volume
- 241
- Issue
- 4871
- Pages
- 1331-1335
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978186903
- Cited by
- 427
- References
- 2
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goebl, M. G., Yochem, J., Jentsch, S., McGrath, J. P., Varshavsky, A., & Byers, B. (1988). The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme. Science. https://doi.org/10.1126/science.2842867
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