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Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

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BH3-only proteins: Orchestrators of apoptosis

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The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

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Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma

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Peptide therapeutics: Targeting the undruggable space

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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

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The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

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Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling

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Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer

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Mitochondria as therapeutic targets for cancer chemotherapy

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How the Bcl-2 family of proteins interact to regulate apoptosis

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Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

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Glioma stem cells: a midterm exam.

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BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

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Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

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Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

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Identification of Direct Protein Targets of Small Molecules

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Assessing Helical Protein Interfaces for Inhibitor Design

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Mitochondrial gateways to cancer

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Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities

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Stapled Helical Peptides Bearing Different Anchoring Residues

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Modulating protein–protein interactions: the potential of peptides

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Contemporary strategies for the stabilization of peptides in the α-helical conformation

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Hydrocarbon Stapled Peptides as Modulators of Biological Function

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Recognizing and exploiting differences between RNAi and small-molecule inhibitors

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Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

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A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

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Apoptosis-based therapies and drug targets

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The mitochondrial death pathway: a promising therapeutic target in diseases

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Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

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Strategies for Improving Peptide Stability and Delivery

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Inhibition of protein–protein interactions using designed molecules

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Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

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Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways.

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Abstract SY37-01: Dissecting the canonical and noncanonical interactions of the BCL-2 family for therapeutic benefit

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Dissecting the BCL‐2 family interaction network with stapled peptides: mechanistic insights and pharmacologic opportunities

Walensky, L. D. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.220.1

Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix.

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Chapter 22 Synthesis and Biophysical Characterization of Stabilized α‐Helices of BCL‐2 Domains

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