The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Impaired Fas Response and Autoimmunity in Pten +/− Mice
Abstract
Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by tumor susceptibility. Here it is shown that Pten heterozygous ( Pten +/− ) mutants develop a lethal polyclonal autoimmune disorder with features reminiscent of those observed in Fas-deficient mutants. Fas-mediated apoptosis was impaired in Pten +/− mice, and T lymphocytes from these mice show reduced activation-induced cell death and increased proliferation upon activation. Phosphatidylinositol (PI) 3-kinase inhibitors restored Fas responsiveness in Pten +/− cells. These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis.
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Marsh, D. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.3.507 · Cited by 653
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Metadata
- Authors
- Cristofano, A. D., Kotsi, P., Peng, Y. F., Cordon-Cardo, C., Elkon, K. B., & Pandolfi, P. P.
- Venue
- Science
- Published
- 1999-09-24
- Volume
- 285
- Issue
- 5436
- Pages
- 2122-2125
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157023326
- Cited by
- 521
- References
- 2
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cristofano, A. D., Kotsi, P., Peng, Y. F., Cordon-Cardo, C., Elkon, K. B., & Pandolfi, P. P. (1999). Impaired Fas Response and Autoimmunity in Pten +/− Mice. Science. https://doi.org/10.1126/science.285.5436.2122
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