Cited by 3,330PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, Jeffrey A., Luo, Ji, Cantley, Lewis C.·2006·Nature Reviews Genetics

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases.

Integrity signals

Registry

Crossref · 10.1038/nrg1879

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Engelman, J. A., Luo, J., & Cantley, L. C.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Cantley, Lewis C.
Venue
Nature Reviews Genetics
Published
2006-08
Volume
7
Issue
8
Pages
606-619
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2009886463
Cited by
3,330
References
14
Citations by year
2026: 72 · 2025: 129 · 2024: 170 · 2023: 174 · 2022: 174 · 2021: 193 · 2020: 186 · 2019: 162 · 2018: 146 · 2017: 179 · 2016: 170 · 2015: 198 · 2014: 233 · 2013: 205 · 2012: 216
FWCI
9.22
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM041890)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
phosphatidylinositol 3-kinase, lipid kinase, vesicle trafficking, cellular metabolism, cell growth regulation, feedback regulation, signaling crosstalk, diabetes mellitus, cancer, PI3K inhibitors
MeSH terms
Animals, Cells, Multigene Family, Humans, Evolution, Molecular, Phosphatidylinositol 3-Kinases, Cell Growth Processes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review