The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Drosophila S6 Kinase: A Regulator of Cell Size
Abstract
Cell proliferation requires cell growth; that is, cells only divide after they reach a critical size. However, the mechanisms by which cells grow and maintain their appropriate size have remained elusive. Drosophila deficient in the S6 kinase gene ( dS6K ) exhibited an extreme delay in development and a severe reduction in body size. These flies had smaller cells rather than fewer cells. The effect was cell-autonomous, displayed throughout larval development, and distinct from that of ribosomal protein mutants ( Minutes ). Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number.
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Cites
Coordination of growth with cell division in the yeast
JOHNSTON, G., PRINGLE, J., & HARTWELL, L. (1977) · Experimental Cell Research · doi:10.1016/0014-4827(77)90154-9 · Cited by 827
TOR signalling and control of cell growth
Thomas, G., & Hall, M. N. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80078-6 · Cited by 462
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Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
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Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3460561 · Cited by 1,644
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
Metadata
- Authors
- Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S. C., & Thomas, G.
- Venue
- Science
- Published
- 1999-09-24
- Volume
- 285
- Issue
- 5436
- Pages
- 2126-2129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979612739
- Cited by
- 717
- References
- 2
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S. C., & Thomas, G. (1999). Drosophila S6 Kinase: A Regulator of Cell Size. Science. https://doi.org/10.1126/science.285.5436.2126
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