The DOI matches its OpenAlex record; 179 of the 179 references it cites were found in a registry or an index.
The PI3K‒PDK1 connection: more than just a road to PKB
Open accessAbstract
Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been implicated in the regulation of cell growth, proliferation, survival, differentiation and cytoskeletal changes. One of the best characterized targets of PI3K lipid products is the protein kinase Akt or protein kinase B (PKB). In quiescent cells, PKB resides in the cytosol in a low-activity conformation. Upon cellular stimulation, PKB is activated through recruitment to cellular membranes by PI3K lipid products and phosphorylation by 3'-phosphoinositide-dependent kinase-1 (PDK1). Here we review the mechanism by which PKB is activated and the downstream actions of this multifunctional kinase. We also discuss the evidence that PDK1 may be involved in the activation of protein kinases other than PKB, the mechanisms by which this activity of PDK1 could be regulated and the possibility that some of the currently postulated PKB substrates targets might in fact be phosphorylated by PDK1-regulated kinases other than PKB.
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Cites
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Cited by
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
Neurotrophin signal transduction in the nervous system
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TOR, a Central Controller of Cell Growth
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Redox regulation of cell survival
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Metadata
- Authors
- Vanhaesebroeck, B., & Alessi, D. R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press
- Published
- 2000-03-07
- Volume
- 346
- Issue
- 3
- Pages
- 561-561
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2039193709
- Cited by
- 1,644
- References
- 179
- FWCI
- 50.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vanhaesebroeck, B., & Alessi, D. R. (2000). The PI3K‒PDK1 connection: more than just a road to PKB. Biochemical Journal. https://doi.org/10.1042/0264-6021%3A3460561
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
