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Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes
Open accessAbstract
Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Here, the isolation of the gene for an enzyme that can hydrolyze the bond between this protein and DNA is described. Enzyme-defective mutants of yeast are hypersensitive to treatments that increase the amount of covalent complexes, indicative of enzyme involvement in repair. The gene is conserved in eukaryotes and identifies a family of enzymes that has not been previously recognized. The presence of this gene in humans may have implications for the effectiveness of topoisomerase I poisons, such as the camptothecins, in chemotherapy.
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Metadata
- Authors
- Pouliot, J. J., Yao, K. C., Robertson, C. A., & Nash, H. A.
- Venue
- Science
- Published
- 1999-10-15
- Volume
- 286
- Issue
- 5439
- Pages
- 552-555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005110566
- Cited by
- 382
- References
- 0
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Pouliot, J. J., Yao, K. C., Robertson, C. A., & Nash, H. A. (1999). Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes. Science. https://doi.org/10.1126/science.286.5439.552
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