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An Adenosine Deaminase that Generates Inosine at the Wobble Position of tRNAs
Open accessAbstract
Several transfer RNAs (tRNAs) contain inosine (I) at the first position of their anticodon (position 34); this modification is thought to enlarge the codon recognition capacity during protein synthesis. The tRNA-specific adenosine deaminase of Saccharomyces cerevisiae that forms I 34 in tRNAs is described. The heterodimeric enzyme consists of two sequence-related subunits (Tad2p/ADAT2 and Tad3p/ADAT3), both of which contain cytidine deaminase (CDA) motifs. Each subunit is encoded by an essential gene ( TAD2 and TAD3 ), indicating that I 34 is an indispensable base modification in elongating tRNAs. These results provide an evolutionary link between the CDA superfamily and RNA-dependent adenosine deaminases (ADARs/ADATs).
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Cites
Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae
SPINGOLA, M., GRATE, L., HAUSSLER, D., & ARES, M. (1999) · RNA · doi:10.1017/s1355838299981682 · Cited by 316
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Anantharaman, V. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.7.1427 · Cited by 541
Lellek, H., Kirsten, R., Diehl, I., Apostel, F., Buck, F., & Greeve, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001786200 · Cited by 150
D'Silva, S., Haider, S. J., & Phizicky, E. M. (2011) · RNA · doi:10.1261/rna.2652611 · Cited by 83
Ling, J., Roy, H., Qin, D., Rubio, M. A. T., Alfonzo, J. D., Fredrick, K., & Ibba, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704441104 · Cited by 45
Metadata
- Authors
- Gerber, A. P., & Keller, W.
- Venue
- Science
- Published
- 1999-11-05
- Volume
- 286
- Issue
- 5442
- Pages
- 1146-1149
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006178602
- Cited by
- 321
- References
- 1
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Gerber, A. P., & Keller, W. (1999). An Adenosine Deaminase that Generates Inosine at the Wobble Position of tRNAs. Science. https://doi.org/10.1126/science.286.5442.1146
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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