The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Activation of PPARγ Coactivator-1 Through Transcription Factor Docking
Abstract
Transcriptional coactivators have been viewed as constitutively active components, using transcription factors mainly to localize their functions. Here, it is shown that PPARγ coactivator–1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator–1 (SRC-1) and CREB binding protein (CBP)/p300. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. The docking of PGC-1 to peroxisome proliferator-activated receptor γ (PPARγ) stimulates an apparent conformational change in PGC-1 that permits binding of SRC-1 and CBP/p300, resulting in a large increase in transcriptional activity. Thus, transcription factor docking switches on the activity of a coactivator protein.
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Cites
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533
Hamamori, Y., Sartorelli, V., Ogryzko, V., Puri, P. L., Wu, H.-Y., Wang, J. Y. J., Nakatani, Y., & Kedes, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80553-x · Cited by 368
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
“While they have not been found to encode any histone acetyltransferase (HAT) activities in their primary sequence, they bind several powerful HAT-containing proteins at their N-terminal regions, including CBP, p300, and SRC-1 (Puigserver et al., 1999).”
BackgroundSelf-citationPuigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Self-citationControl of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
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Metadata
- Authors
- Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O'Malley, B., & Spiegelman, B. M.
- Venue
- Science
- Published
- 1999-11-12
- Volume
- 286
- Issue
- 5443
- Pages
- 1368-1371
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046566365
- Cited by
- 596
- References
- 2
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O'Malley, B., & Spiegelman, B. M. (1999). Activation of PPARγ Coactivator-1 Through Transcription Factor Docking. Science. https://doi.org/10.1126/science.286.5443.1368
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