Cited by 533Genomics and Chromatin DynamicsChromatin Remodeling and CancerCancer-related Molecular Pathways

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

Arany, Zoltan, Newsome, David, Oldread, Elizabeth, Livingston, David M., Eckner, Richard·1995·Nature

Abstract

The cellular protein p300 is a target of the adenoviral E1A oncoprotein and is thought to participate in preventing the G0/G1 transition in the cell cycle, activating certain enhancers and stimulating differentiation pathways. CBP is a protein that is associated with and coactivates the transcription factor CREB, mediating the induction by cyclic AMP of certain responsive promoters. The sequences of p300 and CBP are highly related. We show here that p300, like CBP2, can stimulate transcription. This activity is directly and specifically inhibited by E1A. We also find that CBP exists in a DNA-bound complex containing a member of the CREB family and that E1A and CBP interact with one another in vivo. In keeping with the idea that E1A functionally targets CBP, cAMP-dependent transcription is repressed by E1A. Thus, p300 and CBP define a family of transcriptional adaptor proteins that are specifically targeted by the E1A oncoprotein.

Integrity signals

Registry

Crossref · 10.1038/374081a0

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • CBP is a ubiquitous adapter protein that links transcription factors to the basal transcription machinery and is thought to stimulate transcription through contact with RNA polymerase II and histone acetylation.

    “CBP is a ubiquitous adapter protein that mediates contacts between transcription factors and the basal transcription machinery (1,26,33) and is thought to stimulate transcription both by physical contact with the RNA polymerase II complex and through intrinsic histone acetylation activity (4, 33, 52).”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R.
Affiliations
Harvard University (US)
Venue
Nature
Published
1995-03
Volume
374
Issue
6517
Pages
81-84
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2010605653
Cited by
533
References
28
Citations by year
2025: 1 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
20.78
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
P300, CBP, transcriptional coactivator, CREB, cAMP-dependent transcription, adenovirus E1A, protein-protein interaction, G0/G1 cell cycle arrest, transcriptional repression
MeSH terms
Cyclic AMP, DNA, Humans, Nuclear Proteins, Protein Binding, Recombinant Fusion Proteins, Transcription Factors, Transfection, Tumor Cells, Cultured, Transcriptional Activation, Trans-Activators, Adenovirus E1A Proteins, CREB-Binding Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review