The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
Abstract
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
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Citations
Cites
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide.
Somerville, J. E., Cassiano, L., Bainbridge, B., Cunningham, M. D., & Darveau, R. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118423 · Cited by 275
Cited by
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Gellatly, S. L., & Hancock, R. E. W. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12033 · Cited by 1,295
Cationic peptides: effectors in innate immunity and novel antimicrobials
Hancock, R. E. (2001) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00092-5 · Cited by 978
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Metadata
- Authors
- Ernst, R. K., Yi, E. C., Guo, L., Lim, K. B., Burns, J. L., Hackett, M., & Miller, S. I.
- Venue
- Science
- Published
- 1999-11-19
- Volume
- 286
- Issue
- 5444
- Pages
- 1561-1565
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993513102
- Cited by
- 484
- References
- 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ernst, R. K., Yi, E. C., Guo, L., Lim, K. B., Burns, J. L., Hackett, M., & Miller, S. I. (1999). Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa. Science. https://doi.org/10.1126/science.286.5444.1561
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
