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Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex
Open accessAbstract
Neurokinin-1 receptor (NK1R) and μ-opioid receptor (μOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R + neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and μORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and μORs generate respiratory rhythm and modulate respiratory frequency.
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Cited by
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Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Del Negro, C. A., Funk, G. D., & Feldman, J. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0003-6 · Cited by 663
Self-citationRespiratory control by ventral surface chemoreceptor neurons in rats
Mulkey, D. K., Stornetta, R. L., Weston, M. C., Simmons, J. R., Parker, A., Bayliss, D. A., & Guyenet, P. G. (2004) · Nature Neuroscience · doi:10.1038/nn1357 · Cited by 560
Understanding the Rhythm of Breathing: So Near, Yet So Far
Feldman, J. L., Del Negro, C. A., & Gray, P. A. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-040510-130049 · Cited by 459
Self-citationDistinct rhythm generators for inspiration and expiration in the juvenile rat
Janczewski, W. A., & Feldman, J. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098848 · Cited by 403
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Metadata
- Authors
- Gray, P. A., Rekling, J. C., Bocchiaro, C. M., & Feldman, J. L.
- Venue
- Science
- Published
- 1999-11-19
- Volume
- 286
- Issue
- 5444
- Pages
- 1566-1568
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000744528
- Cited by
- 617
- References
- 0
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Gray, P. A., Rekling, J. C., Bocchiaro, C. M., & Feldman, J. L. (1999). Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex. Science. https://doi.org/10.1126/science.286.5444.1566
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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