The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Distinct rhythm generators for inspiration and expiration in the juvenile rat
Open accessAbstract
Inspiration and active expiration are commonly viewed as antagonistic phases of a unitary oscillator that generates respiratory rhythm. This view conflicts with observations we report here in juvenile rats, where by administration of fentanyl, a selective μ‐opiate agonist, and induction of lung reflexes, we separately manipulated the frequency of inspirations and expirations. Moreover, completely transecting the brainstem at the caudal end of the facial nucleus abolished active expirations, while rhythmic inspirations continued. We hypothesize that inspiration and expiration are generated by coupled, anatomically separate rhythm generators, one generating active expiration located close to the facial nucleus in the region of the retrotrapezoid nucleus/parafacial respiratory group, the other generating inspiration located more caudally in the preBötzinger Complex.
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Cites
Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals
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Self-citationRespiratory control by ventral surface chemoreceptor neurons in rats
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Self-citationA Novel Functional Neuron Group for Respiratory Rhythm Generation in the Ventral Medulla
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Self-citationlocomotor activity in a spinal cord-indlimb muscles preparation of the newborn rat studied in vitro
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Cited by
Del Negro, C. A., Funk, G. D., & Feldman, J. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0003-6 · Cited by 663
Self-citationIncidence, reversal, and prevention of opioid-induced respiratory depression
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Understanding the Rhythm of Breathing: So Near, Yet So Far
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Self-citationA novel excitatory network for the control of breathing
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Efferent projections of excitatory and inhibitory preBötzinger Complex neurons
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Metadata
- Authors
- Janczewski, W. A., & Feldman, J. L.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 570
- Issue
- 2
- Pages
- 407-420
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2006410388
- Cited by
- 403
- References
- 39
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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