The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)
Abstract
Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of a different signaling pathway that also regulates these responses, interacted with Raf and phosphorylated this protein at a highly conserved serine residue in its regulatory domain in vivo. This phosphorylation of Raf by Akt inhibited activation of the Raf-MEK-ERK signaling pathway and shifted the cellular response in a human breast cancer cell line from cell cycle arrest to proliferation. These observations provide a molecular basis for cross talk between two signaling pathways at the level of Raf and Akt.
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Cites
Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284
Cited by
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
ZHANG, W., & LIU, H. T. (2002) · Cell Research · doi:10.1038/sj.cr.7290105 · Cited by 2,845
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464
“As Akt suppresses MAPK signaling by phosphorylating and inhibiting Raf (Zimmermann and Moelling, 1999), it is conceivable that the activation of Akt that occurs in Ragulator null cells could account, at least in part, for the inhibition of MAPK signaling that has been observed in these cells.”
BackgroundEpidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Wee, P., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050052 · Cited by 2,027
Metadata
- Authors
- Zimmermann, S., & Moelling, K.
- Venue
- Science
- Published
- 1999-11-26
- Volume
- 286
- Issue
- 5445
- Pages
- 1741-1744
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971727526
- Cited by
- 1,078
- References
- 1
- FWCI
- 22.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zimmermann, S., & Moelling, K. (1999). Phosphorylation and Regulation of Raf by Akt (Protein Kinase B). Science. https://doi.org/10.1126/science.286.5445.1741
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
