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Stimulation of Bone Formation in Vitro and in Rodents by Statins
Abstract
Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein–2 ( BMP-2 ) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis.
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Citations
Cited by
PLEIOTROPIC EFFECTS OF STATINS
Liao, J. K., & Laufs, U. (2005) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095748 · Cited by 1,994
Therapeutic Approaches to Bone Diseases
Rodan, G. A., & Martin, T. J. (2000) · Science · doi:10.1126/science.289.5484.1508 · Cited by 1,767
Structural mechanism for statin inhibition of HMG-CoA reductase
Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644
Periodontitis and cardiovascular diseases: Consensus report
Sanz, M., Marco del Castillo, A., Jepsen, S., Gonzalez‐Juanatey, J. R., D’Aiuto, F., Bouchard, P., Chapple, I., Dietrich, T., Gotsman, I., Graziani, F., et al. (2020) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13189 · Cited by 1,482
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F., Reynolds, C., Zimmerman, R., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,049
Metadata
- Authors
- Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., & Gutierrez, G.
- Venue
- Science
- Published
- 1999-12-03
- Volume
- 286
- Issue
- 5446
- Pages
- 1946-1949
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020364703
- Cited by
- 1,774
- References
- 0
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., & Gutierrez, G. (1999). Stimulation of Bone Formation in Vitro and in Rodents by Statins. Science. https://doi.org/10.1126/science.286.5446.1946
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
