The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
Abstract
Natural antibodies are often dismissed from immunological analysis as “background,” but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes , viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.
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Citations
Cites
Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’
Avrameas, S. (1991) · Immunology Today · doi:10.1016/s0167-5699(05)80045-3 · Cited by 766
Cited by
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2868 · Cited by 2,106
Predominant Autoantibody Production by Early Human B Cell Precursors
Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., & Nussenzweig, M. C. (2003) · Science · doi:10.1126/science.1086907 · Cited by 2,083
Chiorazzi, N., Rai, K. R., & Ferrarini, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041720 · Cited by 1,296
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846
Metadata
- Authors
- Ochsenbein, A. F., Fehr, T., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M.
- Venue
- Science
- Published
- 1999-12-10
- Volume
- 286
- Issue
- 5447
- Pages
- 2156-2159
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044098624
- Cited by
- 910
- References
- 1
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ochsenbein, A. F., Fehr, T., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999). Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies. Science. https://doi.org/10.1126/science.286.5447.2156
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
